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Acupuncture activates signal transduction pathways related to brain-tissue restoration after ischemic injury☆

A middle cerebral artery occlusion-model was established in rats using the improved thread embolism method. Rats were treated with acupuncture at either Dazhui (DU14), Renzhong (DU26), Baihui (DU20), or a non-meridian point. Detection with protein-chip technology showed that the level of protein pho...

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Autores principales: Tian, Haomei, Zhang, Hong, Zhu, Junbao, Zhang, Juan, Cai, Hening, Zhang, Yuchen, Chen, Chutao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298900/
https://www.ncbi.nlm.nih.gov/pubmed/25624812
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.24.004
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author Tian, Haomei
Zhang, Hong
Zhu, Junbao
Zhang, Juan
Cai, Hening
Zhang, Yuchen
Chen, Chutao
author_facet Tian, Haomei
Zhang, Hong
Zhu, Junbao
Zhang, Juan
Cai, Hening
Zhang, Yuchen
Chen, Chutao
author_sort Tian, Haomei
collection PubMed
description A middle cerebral artery occlusion-model was established in rats using the improved thread embolism method. Rats were treated with acupuncture at either Dazhui (DU14), Renzhong (DU26), Baihui (DU20), or a non-meridian point. Detection with protein-chip technology showed that the level of protein phosphorylation in both groups was upregulated or downregulated depending on the signaling pathway compared with the model group that did not receive acupuncture. Analysis of proteins showing downregulated phosphorylation revealed that five signaling pathways were activated in the acupuncture-treatment group, while only two were activated in the acupuncture- control group. In contrast, analysis of proteins showing upregulated phosphorylation revealed only one pathway was activated in the acupuncture-treatment group, whereas four pathways were activated in the acupuncture-control group. Furthermore, the number of activated proteins in the acupuncture-treatment group was not only higher than the acupuncture-control group, but unlike the acupuncture-control group, the majority of activated proteins were key proteins in the signaling pathways. Our findings indicate that acupuncture at specific points can activate multiple signaling pathways to promote the restoration of brain tissue following ischemic injury, and that this is based on a combination of effects resulting from multiple pathways, targets, and means.
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spelling pubmed-42989002015-01-26 Acupuncture activates signal transduction pathways related to brain-tissue restoration after ischemic injury☆ Tian, Haomei Zhang, Hong Zhu, Junbao Zhang, Juan Cai, Hening Zhang, Yuchen Chen, Chutao Neural Regen Res Research and Report: Acupuncture and Moxibustion and Neural Regeneration A middle cerebral artery occlusion-model was established in rats using the improved thread embolism method. Rats were treated with acupuncture at either Dazhui (DU14), Renzhong (DU26), Baihui (DU20), or a non-meridian point. Detection with protein-chip technology showed that the level of protein phosphorylation in both groups was upregulated or downregulated depending on the signaling pathway compared with the model group that did not receive acupuncture. Analysis of proteins showing downregulated phosphorylation revealed that five signaling pathways were activated in the acupuncture-treatment group, while only two were activated in the acupuncture- control group. In contrast, analysis of proteins showing upregulated phosphorylation revealed only one pathway was activated in the acupuncture-treatment group, whereas four pathways were activated in the acupuncture-control group. Furthermore, the number of activated proteins in the acupuncture-treatment group was not only higher than the acupuncture-control group, but unlike the acupuncture-control group, the majority of activated proteins were key proteins in the signaling pathways. Our findings indicate that acupuncture at specific points can activate multiple signaling pathways to promote the restoration of brain tissue following ischemic injury, and that this is based on a combination of effects resulting from multiple pathways, targets, and means. Medknow Publications & Media Pvt Ltd 2012-08-25 /pmc/articles/PMC4298900/ /pubmed/25624812 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.24.004 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research and Report: Acupuncture and Moxibustion and Neural Regeneration
Tian, Haomei
Zhang, Hong
Zhu, Junbao
Zhang, Juan
Cai, Hening
Zhang, Yuchen
Chen, Chutao
Acupuncture activates signal transduction pathways related to brain-tissue restoration after ischemic injury☆
title Acupuncture activates signal transduction pathways related to brain-tissue restoration after ischemic injury☆
title_full Acupuncture activates signal transduction pathways related to brain-tissue restoration after ischemic injury☆
title_fullStr Acupuncture activates signal transduction pathways related to brain-tissue restoration after ischemic injury☆
title_full_unstemmed Acupuncture activates signal transduction pathways related to brain-tissue restoration after ischemic injury☆
title_short Acupuncture activates signal transduction pathways related to brain-tissue restoration after ischemic injury☆
title_sort acupuncture activates signal transduction pathways related to brain-tissue restoration after ischemic injury☆
topic Research and Report: Acupuncture and Moxibustion and Neural Regeneration
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298900/
https://www.ncbi.nlm.nih.gov/pubmed/25624812
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.24.004
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