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Droplet Microfluidics for Chip-Based Diagnostics
Droplet microfluidics (DMF) is a fluidic handling technology that enables precision control over dispensing and subsequent manipulation of droplets in the volume range of microliters to picoliters, on a micro-fabricated device. There are several different droplet actuation methods, all of which can...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299063/ https://www.ncbi.nlm.nih.gov/pubmed/25490590 http://dx.doi.org/10.3390/s141223283 |
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author | Kaler, Karan V. I. S. Prakash, Ravi |
author_facet | Kaler, Karan V. I. S. Prakash, Ravi |
author_sort | Kaler, Karan V. I. S. |
collection | PubMed |
description | Droplet microfluidics (DMF) is a fluidic handling technology that enables precision control over dispensing and subsequent manipulation of droplets in the volume range of microliters to picoliters, on a micro-fabricated device. There are several different droplet actuation methods, all of which can generate external stimuli, to either actively or passively control the shape and positioning of fluidic droplets over patterned substrates. In this review article, we focus on the operation and utility of electro-actuation-based DMF devices, which utilize one or more micro-/nano-patterned substrates to facilitate electric field-based handling of chemical and/or biological samples. The underlying theory of DMF actuations, device fabrication methods and integration of optical and opto-electronic detectors is discussed in this review. Example applications of such electro-actuation-based DMF devices have also been included, illustrating the various actuation methods and their utility in conducting chip-based laboratory and clinical diagnostic assays. |
format | Online Article Text |
id | pubmed-4299063 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-42990632015-01-26 Droplet Microfluidics for Chip-Based Diagnostics Kaler, Karan V. I. S. Prakash, Ravi Sensors (Basel) Review Droplet microfluidics (DMF) is a fluidic handling technology that enables precision control over dispensing and subsequent manipulation of droplets in the volume range of microliters to picoliters, on a micro-fabricated device. There are several different droplet actuation methods, all of which can generate external stimuli, to either actively or passively control the shape and positioning of fluidic droplets over patterned substrates. In this review article, we focus on the operation and utility of electro-actuation-based DMF devices, which utilize one or more micro-/nano-patterned substrates to facilitate electric field-based handling of chemical and/or biological samples. The underlying theory of DMF actuations, device fabrication methods and integration of optical and opto-electronic detectors is discussed in this review. Example applications of such electro-actuation-based DMF devices have also been included, illustrating the various actuation methods and their utility in conducting chip-based laboratory and clinical diagnostic assays. MDPI 2014-12-05 /pmc/articles/PMC4299063/ /pubmed/25490590 http://dx.doi.org/10.3390/s141223283 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kaler, Karan V. I. S. Prakash, Ravi Droplet Microfluidics for Chip-Based Diagnostics |
title | Droplet Microfluidics for Chip-Based Diagnostics |
title_full | Droplet Microfluidics for Chip-Based Diagnostics |
title_fullStr | Droplet Microfluidics for Chip-Based Diagnostics |
title_full_unstemmed | Droplet Microfluidics for Chip-Based Diagnostics |
title_short | Droplet Microfluidics for Chip-Based Diagnostics |
title_sort | droplet microfluidics for chip-based diagnostics |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299063/ https://www.ncbi.nlm.nih.gov/pubmed/25490590 http://dx.doi.org/10.3390/s141223283 |
work_keys_str_mv | AT kalerkaranvis dropletmicrofluidicsforchipbaseddiagnostics AT prakashravi dropletmicrofluidicsforchipbaseddiagnostics |