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Computational modeling suggests dimerization of equine infectious anemia virus Rev is required for RNA binding

BACKGROUND: The lentiviral Rev protein mediates nuclear export of intron-containing viral RNAs that encode structural proteins or serve as the viral genome. Following translation, HIV-1 Rev localizes to the nucleus and binds its cognate sequence, termed the Rev-responsive element (RRE), in incomplet...

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Detalles Bibliográficos
Autores principales: Umunnakwe, Chijioke N, Loyd, Hyelee, Cornick, Kinsey, Chavez, Jerald R, Dobbs, Drena, Carpenter, Susan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299382/
https://www.ncbi.nlm.nih.gov/pubmed/25533001
http://dx.doi.org/10.1186/s12977-014-0115-7