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Measuring error rates in genomic perturbation screens: gold standards for human functional genomics

Technological advancement has opened the door to systematic genetics in mammalian cells. Genome-scale loss-of-function screens can assay fitness defects induced by partial gene knockdown, using RNA interference, or complete gene knockout, using new CRISPR techniques. These screens can reveal the bas...

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Detalles Bibliográficos
Autores principales:	Hart, Traver, Brown, Kevin R, Sircoulomb, Fabrice, Rottapel, Robert, Moffat, Jason
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2014
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299491/ https://www.ncbi.nlm.nih.gov/pubmed/24987113 http://dx.doi.org/10.15252/msb.20145216

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