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Clinical value of wireless pH-monitoring of gastro-esophageal reflux in children before and after proton pump inhibitors
BACKGROUND: Wireless pH-monitoring is an accurate method for diagnosing adults with gastroesophageal reflux disease (GERD). The aim of this study was to evaluate the use of the Bravo capsule on children investigated for GERD in terms of safety, tolerability and feasibility before and after administr...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299672/ https://www.ncbi.nlm.nih.gov/pubmed/25539736 http://dx.doi.org/10.1186/s12876-014-0225-7 |
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author | Boström, Michaela Thorsson, Ola Toth, Ervin Agardh, Daniel |
author_facet | Boström, Michaela Thorsson, Ola Toth, Ervin Agardh, Daniel |
author_sort | Boström, Michaela |
collection | PubMed |
description | BACKGROUND: Wireless pH-monitoring is an accurate method for diagnosing adults with gastroesophageal reflux disease (GERD). The aim of this study was to evaluate the use of the Bravo capsule on children investigated for GERD in terms of safety, tolerability and feasibility before and after administration of proton pump inhibitors. METHODS: A Bravo capsule was inserted during upper endoscopy under general anaesthesia or deep sedation with propofol. 48-hour pH-metry was performed in 106 children (50 males, 56 females) at the median age of 11 years (range 17 months-18 years). On the second day of investigation, proton pump inhibitor (PPI) was given at a mean dose of 1.6 mg/kg (SD ±0.6 mg). The definition of GERD was set to a reflux index (RI) of ≥5% and DeMeester score (DMS) ≥14.7. RESULTS: Application of the capsule was successful in 103 of the 106 children (97.2%) and interpretable in 99 of these 103 (96.1%). 49 of the children with interpretable results (49.5%) had GERD according to RI, while 51 (56.7%) had GERD according to DMS. After PPI was given on day 2, RI decreased from a median of 4.9% (range 0.3-63.4%) to 2.2% (0–58.0%), while DMS decreased from a median of 17.6 (range 2.2-207.6) to 8.2 (0.3-178.6), respectively (p < 0.0001). No severe adverse events were reported. CONCLUSION: Wireless pH-metry is a safe and tolerable method when investigating children for GERD. PPI given on the second day of assessment provides additional information on response to treatment suggesting that pH-metry preferably should be extended to 48 hours. |
format | Online Article Text |
id | pubmed-4299672 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-42996722015-01-21 Clinical value of wireless pH-monitoring of gastro-esophageal reflux in children before and after proton pump inhibitors Boström, Michaela Thorsson, Ola Toth, Ervin Agardh, Daniel BMC Gastroenterol Research Article BACKGROUND: Wireless pH-monitoring is an accurate method for diagnosing adults with gastroesophageal reflux disease (GERD). The aim of this study was to evaluate the use of the Bravo capsule on children investigated for GERD in terms of safety, tolerability and feasibility before and after administration of proton pump inhibitors. METHODS: A Bravo capsule was inserted during upper endoscopy under general anaesthesia or deep sedation with propofol. 48-hour pH-metry was performed in 106 children (50 males, 56 females) at the median age of 11 years (range 17 months-18 years). On the second day of investigation, proton pump inhibitor (PPI) was given at a mean dose of 1.6 mg/kg (SD ±0.6 mg). The definition of GERD was set to a reflux index (RI) of ≥5% and DeMeester score (DMS) ≥14.7. RESULTS: Application of the capsule was successful in 103 of the 106 children (97.2%) and interpretable in 99 of these 103 (96.1%). 49 of the children with interpretable results (49.5%) had GERD according to RI, while 51 (56.7%) had GERD according to DMS. After PPI was given on day 2, RI decreased from a median of 4.9% (range 0.3-63.4%) to 2.2% (0–58.0%), while DMS decreased from a median of 17.6 (range 2.2-207.6) to 8.2 (0.3-178.6), respectively (p < 0.0001). No severe adverse events were reported. CONCLUSION: Wireless pH-metry is a safe and tolerable method when investigating children for GERD. PPI given on the second day of assessment provides additional information on response to treatment suggesting that pH-metry preferably should be extended to 48 hours. BioMed Central 2014-12-24 /pmc/articles/PMC4299672/ /pubmed/25539736 http://dx.doi.org/10.1186/s12876-014-0225-7 Text en © Boström et al.; licensee BioMed Central. 2014 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Boström, Michaela Thorsson, Ola Toth, Ervin Agardh, Daniel Clinical value of wireless pH-monitoring of gastro-esophageal reflux in children before and after proton pump inhibitors |
title | Clinical value of wireless pH-monitoring of gastro-esophageal reflux in children before and after proton pump inhibitors |
title_full | Clinical value of wireless pH-monitoring of gastro-esophageal reflux in children before and after proton pump inhibitors |
title_fullStr | Clinical value of wireless pH-monitoring of gastro-esophageal reflux in children before and after proton pump inhibitors |
title_full_unstemmed | Clinical value of wireless pH-monitoring of gastro-esophageal reflux in children before and after proton pump inhibitors |
title_short | Clinical value of wireless pH-monitoring of gastro-esophageal reflux in children before and after proton pump inhibitors |
title_sort | clinical value of wireless ph-monitoring of gastro-esophageal reflux in children before and after proton pump inhibitors |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299672/ https://www.ncbi.nlm.nih.gov/pubmed/25539736 http://dx.doi.org/10.1186/s12876-014-0225-7 |
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