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Cerebro-cerebellar connectivity is increased in primary lateral sclerosis
Increased functional connectivity in resting state networks was found in several studies of patients with motor neuron disorders, although diffusion tensor imaging studies consistently show loss of white matter integrity. To understand the relationship between structural connectivity and functional...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300015/ https://www.ncbi.nlm.nih.gov/pubmed/25610792 http://dx.doi.org/10.1016/j.nicl.2014.12.009 |
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author | Meoded, Avner Morrissette, Arthur E. Katipally, Rohan Schanz, Olivia Gotts, Stephen J. Floeter, Mary Kay |
author_facet | Meoded, Avner Morrissette, Arthur E. Katipally, Rohan Schanz, Olivia Gotts, Stephen J. Floeter, Mary Kay |
author_sort | Meoded, Avner |
collection | PubMed |
description | Increased functional connectivity in resting state networks was found in several studies of patients with motor neuron disorders, although diffusion tensor imaging studies consistently show loss of white matter integrity. To understand the relationship between structural connectivity and functional connectivity, we examined the structural connections between regions with altered functional connectivity in patients with primary lateral sclerosis (PLS), a long-lived motor neuron disease. Connectivity matrices were constructed from resting state fMRI in 16 PLS patients to identify areas of differing connectivity between patients and healthy controls. Probabilistic fiber tracking was used to examine structural connections between regions of differing connectivity. PLS patients had 12 regions with increased functional connectivity compared to controls, with a predominance of cerebro-cerebellar connections. Increased functional connectivity was strongest between the cerebellum and cortical motor areas and between the cerebellum and frontal and temporal cortex. Fiber tracking detected no difference in connections between regions with increased functional connectivity. We conclude that functional connectivity changes are not strongly based in structural connectivity. Increased functional connectivity may be caused by common inputs, or by reduced selectivity of cortical activation, which could result from loss of intracortical inhibition when cortical afferents are intact. |
format | Online Article Text |
id | pubmed-4300015 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-43000152015-01-21 Cerebro-cerebellar connectivity is increased in primary lateral sclerosis Meoded, Avner Morrissette, Arthur E. Katipally, Rohan Schanz, Olivia Gotts, Stephen J. Floeter, Mary Kay Neuroimage Clin Regular Article Increased functional connectivity in resting state networks was found in several studies of patients with motor neuron disorders, although diffusion tensor imaging studies consistently show loss of white matter integrity. To understand the relationship between structural connectivity and functional connectivity, we examined the structural connections between regions with altered functional connectivity in patients with primary lateral sclerosis (PLS), a long-lived motor neuron disease. Connectivity matrices were constructed from resting state fMRI in 16 PLS patients to identify areas of differing connectivity between patients and healthy controls. Probabilistic fiber tracking was used to examine structural connections between regions of differing connectivity. PLS patients had 12 regions with increased functional connectivity compared to controls, with a predominance of cerebro-cerebellar connections. Increased functional connectivity was strongest between the cerebellum and cortical motor areas and between the cerebellum and frontal and temporal cortex. Fiber tracking detected no difference in connections between regions with increased functional connectivity. We conclude that functional connectivity changes are not strongly based in structural connectivity. Increased functional connectivity may be caused by common inputs, or by reduced selectivity of cortical activation, which could result from loss of intracortical inhibition when cortical afferents are intact. Elsevier 2014-12-09 /pmc/articles/PMC4300015/ /pubmed/25610792 http://dx.doi.org/10.1016/j.nicl.2014.12.009 Text en http://creativecommons.org/licenses/by/3.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Regular Article Meoded, Avner Morrissette, Arthur E. Katipally, Rohan Schanz, Olivia Gotts, Stephen J. Floeter, Mary Kay Cerebro-cerebellar connectivity is increased in primary lateral sclerosis |
title | Cerebro-cerebellar connectivity is increased in primary lateral sclerosis |
title_full | Cerebro-cerebellar connectivity is increased in primary lateral sclerosis |
title_fullStr | Cerebro-cerebellar connectivity is increased in primary lateral sclerosis |
title_full_unstemmed | Cerebro-cerebellar connectivity is increased in primary lateral sclerosis |
title_short | Cerebro-cerebellar connectivity is increased in primary lateral sclerosis |
title_sort | cerebro-cerebellar connectivity is increased in primary lateral sclerosis |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300015/ https://www.ncbi.nlm.nih.gov/pubmed/25610792 http://dx.doi.org/10.1016/j.nicl.2014.12.009 |
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