Involvement of peroxisome proliferator-activated receptors in cardiac and vascular remodeling in a novel minipig model of insulin resistance and atherosclerosis induced by consumption of a high-fat/cholesterol diet

BACKGROUND: A long-term high-fat/cholesterol (HFC) diet leads to insulin resistance (IR), which is associated with inflammation, atherosclerosis (AS), cardiac sympathovagal imbalance, and cardiac dysfunction. Peroxisome proliferator-activated receptors (PPARs) and nuclear factor ĸB (NF-κB) are invol...

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Detalles Bibliográficos
Autores principales: Yongming, Pan, Zhaowei, Cai, Yichao, Ma, Keyan, Zhu, Liang, Chen, Fangming, Chen, Xiaoping, Xu, Quanxin, Ma, Minli, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300051/
https://www.ncbi.nlm.nih.gov/pubmed/25592139
http://dx.doi.org/10.1186/s12933-014-0165-0

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