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Effects of Intermittent Positive Pressure Ventilation on Cardiopulmonary Function in Horses Anesthetized with Total Intravenous Anesthesia Using Combination of Medetomidine, Lidocaine, Butorphanol and Propofol (MLBP-TIVA)

Effects of intermittent positive pressure ventilation (IPPV) on cardiopulmonary function were evaluated in horses anesthetized with total intravenous anesthesia using constant rate infusions of medetomidine (3.5 µg/kg/hr), lidocaine (3 mg/kg/hr), butorphanol (24 µg/kg/hr) and propofol (0.1 mg/kg/min...

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Autores principales: ISHIZUKA, Tomohito, TAMURA, Jun, NAGARO, Tsukasa, SUDO, Kanako, ITAMI, Takaharu, UMAR, Mohammed Ahamed, MIYOSHI, Kenjirou, SANO, Tadashi, YAMASHITA, Kazuto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300371/
https://www.ncbi.nlm.nih.gov/pubmed/25649938
http://dx.doi.org/10.1292/jvms.14-0077
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author ISHIZUKA, Tomohito
TAMURA, Jun
NAGARO, Tsukasa
SUDO, Kanako
ITAMI, Takaharu
UMAR, Mohammed Ahamed
MIYOSHI, Kenjirou
SANO, Tadashi
YAMASHITA, Kazuto
author_facet ISHIZUKA, Tomohito
TAMURA, Jun
NAGARO, Tsukasa
SUDO, Kanako
ITAMI, Takaharu
UMAR, Mohammed Ahamed
MIYOSHI, Kenjirou
SANO, Tadashi
YAMASHITA, Kazuto
author_sort ISHIZUKA, Tomohito
collection PubMed
description Effects of intermittent positive pressure ventilation (IPPV) on cardiopulmonary function were evaluated in horses anesthetized with total intravenous anesthesia using constant rate infusions of medetomidine (3.5 µg/kg/hr), lidocaine (3 mg/kg/hr), butorphanol (24 µg/kg/hr) and propofol (0.1 mg/kg/min) (MLBP-TIVA). Five horses were anesthetized twice using MLBP-TIVA with or without IPPV at 4-week interval (crossover study). In each occasion, the horses breathed 100% oxygen with spontaneous ventilation (SB-group, n=5) or with IPPV (CV-group, n=5), and changes in cardiopulmonary parameters were observed for 120 min. In the SB-group, cardiovascular parameters were maintained within acceptable ranges (heart rate: 33–35 beats/min, cardiac output: 27–30 l/min, mean arterial blood pressure [MABP]: 114–123 mmHg, mean pulmonary arterial pressure [MPAP]: 28–29 mmHg and mean right atrial pressure [MRAP]: 19–21 mmHg), but severe hypercapnea and insufficient oxygenation were observed (arterial CO(2) pressure [PaCO(2)]: 84–103 mmHg and arterial O(2) pressure [PaO(2)]: 155–172 mmHg). In the CV-group, normocapnea (PaCO(2): 42–50 mmHg) and good oxygenation (PaO(2): 395–419 mmHg) were achieved by the IPPV without apparent cardiovascular depression (heart rate: 29–31 beats/min, cardiac output: 17–21 l /min, MABP: 111–123 mmHg, MPAP: 27–30 mmHg and MRAP: 15–16 mmHg). MLBP-TIVA preserved cardiovascular function even in horses artificially ventilated.
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spelling pubmed-43003712015-02-06 Effects of Intermittent Positive Pressure Ventilation on Cardiopulmonary Function in Horses Anesthetized with Total Intravenous Anesthesia Using Combination of Medetomidine, Lidocaine, Butorphanol and Propofol (MLBP-TIVA) ISHIZUKA, Tomohito TAMURA, Jun NAGARO, Tsukasa SUDO, Kanako ITAMI, Takaharu UMAR, Mohammed Ahamed MIYOSHI, Kenjirou SANO, Tadashi YAMASHITA, Kazuto J Vet Med Sci Surgery Effects of intermittent positive pressure ventilation (IPPV) on cardiopulmonary function were evaluated in horses anesthetized with total intravenous anesthesia using constant rate infusions of medetomidine (3.5 µg/kg/hr), lidocaine (3 mg/kg/hr), butorphanol (24 µg/kg/hr) and propofol (0.1 mg/kg/min) (MLBP-TIVA). Five horses were anesthetized twice using MLBP-TIVA with or without IPPV at 4-week interval (crossover study). In each occasion, the horses breathed 100% oxygen with spontaneous ventilation (SB-group, n=5) or with IPPV (CV-group, n=5), and changes in cardiopulmonary parameters were observed for 120 min. In the SB-group, cardiovascular parameters were maintained within acceptable ranges (heart rate: 33–35 beats/min, cardiac output: 27–30 l/min, mean arterial blood pressure [MABP]: 114–123 mmHg, mean pulmonary arterial pressure [MPAP]: 28–29 mmHg and mean right atrial pressure [MRAP]: 19–21 mmHg), but severe hypercapnea and insufficient oxygenation were observed (arterial CO(2) pressure [PaCO(2)]: 84–103 mmHg and arterial O(2) pressure [PaO(2)]: 155–172 mmHg). In the CV-group, normocapnea (PaCO(2): 42–50 mmHg) and good oxygenation (PaO(2): 395–419 mmHg) were achieved by the IPPV without apparent cardiovascular depression (heart rate: 29–31 beats/min, cardiac output: 17–21 l /min, MABP: 111–123 mmHg, MPAP: 27–30 mmHg and MRAP: 15–16 mmHg). MLBP-TIVA preserved cardiovascular function even in horses artificially ventilated. The Japanese Society of Veterinary Science 2014-09-03 2014-12 /pmc/articles/PMC4300371/ /pubmed/25649938 http://dx.doi.org/10.1292/jvms.14-0077 Text en ©2014 The Japanese Society of Veterinary Science http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
spellingShingle Surgery
ISHIZUKA, Tomohito
TAMURA, Jun
NAGARO, Tsukasa
SUDO, Kanako
ITAMI, Takaharu
UMAR, Mohammed Ahamed
MIYOSHI, Kenjirou
SANO, Tadashi
YAMASHITA, Kazuto
Effects of Intermittent Positive Pressure Ventilation on Cardiopulmonary Function in Horses Anesthetized with Total Intravenous Anesthesia Using Combination of Medetomidine, Lidocaine, Butorphanol and Propofol (MLBP-TIVA)
title Effects of Intermittent Positive Pressure Ventilation on Cardiopulmonary Function in Horses Anesthetized with Total Intravenous Anesthesia Using Combination of Medetomidine, Lidocaine, Butorphanol and Propofol (MLBP-TIVA)
title_full Effects of Intermittent Positive Pressure Ventilation on Cardiopulmonary Function in Horses Anesthetized with Total Intravenous Anesthesia Using Combination of Medetomidine, Lidocaine, Butorphanol and Propofol (MLBP-TIVA)
title_fullStr Effects of Intermittent Positive Pressure Ventilation on Cardiopulmonary Function in Horses Anesthetized with Total Intravenous Anesthesia Using Combination of Medetomidine, Lidocaine, Butorphanol and Propofol (MLBP-TIVA)
title_full_unstemmed Effects of Intermittent Positive Pressure Ventilation on Cardiopulmonary Function in Horses Anesthetized with Total Intravenous Anesthesia Using Combination of Medetomidine, Lidocaine, Butorphanol and Propofol (MLBP-TIVA)
title_short Effects of Intermittent Positive Pressure Ventilation on Cardiopulmonary Function in Horses Anesthetized with Total Intravenous Anesthesia Using Combination of Medetomidine, Lidocaine, Butorphanol and Propofol (MLBP-TIVA)
title_sort effects of intermittent positive pressure ventilation on cardiopulmonary function in horses anesthetized with total intravenous anesthesia using combination of medetomidine, lidocaine, butorphanol and propofol (mlbp-tiva)
topic Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300371/
https://www.ncbi.nlm.nih.gov/pubmed/25649938
http://dx.doi.org/10.1292/jvms.14-0077
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