Cargando…

Angiogenin Secretion From Hepatoma Cells Activates Hepatic Stellate Cells To Amplify A Self-Sustained Cycle Promoting Liver Cancer

Hepatocellular carcinoma (HCC) frequently develops in a pro-inflammatory and pro-fibrogenic environment with hepatic stellate cells (HSCs) remodeling the extracellular matrix composition. Molecules secreted by liver tumors contributing to HSC activation and peritumoral stromal transformation remain...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bárcena, Cristina, Stefanovic, Milica, Tutusaus, Anna, Martinez-Nieto, Guillermo A., Martinez, Laura, García-Ruiz, Carmen, de Mingo, Alvaro, Caballeria, Juan, Fernandez-Checa, José C., Marí, Montserrat, Morales, Albert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300499/ https://www.ncbi.nlm.nih.gov/pubmed/25604905 http://dx.doi.org/10.1038/srep07916

Ejemplares similares

Targeting glucosylceramide synthase upregulation reverts sorafenib resistance in experimental hepatocellular carcinoma
por: Stefanovic, Milica, et al.
Publicado: (2016)

Cysteine cathepsins control hepatic NF-κB-dependent inflammation via sirtuin-1 regulation
por: de Mingo, Álvaro, et al.
Publicado: (2016)

Antiapoptotic BCL-2 proteins determine sorafenib/regorafenib resistance and BH3-mimetic efficacy in hepatocellular carcinoma
por: Tutusaus, Anna, et al.
Publicado: (2018)

Differential Role of Cathepsins S and B In Hepatic APC-Mediated NKT Cell Activation and Cytokine Secretion
por: de Mingo Pulido, Álvaro, et al.
Publicado: (2018)

Herbal compound “Songyou Yin” attenuates hepatoma cell invasiveness and metastasis through downregulation of cytokines secreted by activated hepatic stellate cells
por: Jia, Qing-An, et al.
Publicado: (2013)

Molecular basis for the autonomous promotion of cell proliferation by angiogenin
por: Hoang, Trish T., et al.
Publicado: (2017)

Human angiogenin, an organogenic protein.
por: Riordan, J. F., et al.
Publicado: (1988)

Regorafenib Alteration of the BCL-xL/MCL-1 Ratio Provides a Therapeutic Opportunity for BH3-Mimetics in Hepatocellular Carcinoma Models
por: Cucarull, Blanca, et al.
Publicado: (2020)

Crystal structures of murine angiogenin-2 and -3 – probing ‘structure – function’ relationships amongst angiogenin homologues
por: Iyer, Shalini, et al.
Publicado: (2013)

Extracellular vesicles from senescent hepatic stellate cells promote cell viability of hepatoma cells through increasing EGF secretion from differentiated THP-1 cells
por: Miyazoe, Yuri, et al.
Publicado: (2020)

Angiogenin in age-related macular degeneration
por: Skeie, Jessica M., et al.
Publicado: (2011)

Mutational dynamics of murine angiogenin duplicates
por: Codoñer, Francisco M, et al.
Publicado: (2010)

Angiogenin and osteopontin and coronary collateral circulation
por: Beuy, Joob, et al.
Publicado: (2019)

Angiogenin and Copper Crossing in Wound Healing
por: Cucci, Lorena Maria, et al.
Publicado: (2021)

Amplified Inhibition of Stellate Cell Activation Pathways by PPAR-γ, RAR and RXR Agonists
por: Sharvit, Efrat, et al.
Publicado: (2013)

Dual function of angiogenin-4 inducing intestinal stem cells and apoptosis
por: Abo, Hirohito, et al.
Publicado: (2023)

Angiogenin in Parkinson Disease Models: Role of Akt Phosphorylation and Evaluation of AAV-Mediated Angiogenin Expression in MPTP Treated Mice
por: Steidinger, Trent U., et al.
Publicado: (2013)

Molecular Mechanisms in Amyotrophic Lateral Sclerosis: The Role of Angiogenin, a Secreted RNase
por: Aparicio-Erriu, Isabela M., et al.
Publicado: (2012)

Epigenetic Mechanisms in Hepatic Stellate Cell Activation During Liver Fibrosis and Carcinogenesis
por: Barcena-Varela, Marina, et al.
Publicado: (2019)

Angiogenin for the Diagnosis and Grading of Dry Eye Syndrome
por: Kim, Won Soo, et al.
Publicado: (2016)

Mutational Analysis of Angiogenin Gene in Parkinson's Disease
por: Chen, Meng-Ling, et al.
Publicado: (2014)

Angiogenin in the Neurogenic Subventricular Zone After Stroke
por: Gabriel-Salazar, Marina, et al.
Publicado: (2021)

Microarray data and pathway analyses for primary human activated hepatic stellate cells compared to HepG2 human hepatoma cells
por: Hetherington, Alexandra M., et al.
Publicado: (2016)

A study of chromosomal changes associated with amplified dihydrofolate reductase genes in rat hepatoma cells and their dedifferentiated variants
Publicado: (1984)

The Antimicrobial Peptides Human β-Defensins Induce the Secretion of Angiogenin in Human Dermal Fibroblasts
por: Umehara, Yoshie, et al.
Publicado: (2022)

Angiogenin and tRNA fragments in Parkinson’s disease and neurodegeneration
por: Prehn, Jochen H M, et al.
Publicado: (2020)

Role of circulating angiogenin levels in portal hypertension and TIPS
por: Queck, Alexander, et al.
Publicado: (2021)

Dimerization of Human Angiogenin and of Variants Involved in Neurodegenerative Diseases
por: Fasoli, Sabrina, et al.
Publicado: (2021)

Characterization and Function of the Interaction of Angiogenin With Alpha-Actinin 2
por: Weng, Chunhua, et al.
Publicado: (2022)

Gold Nanoparticles Functionalized with Angiogenin for Wound Care Application
por: Cucci, Lorena Maria, et al.
Publicado: (2021)

Structure of angiogenin dimer bound to double-stranded RNA
por: Sievers, Katharina, et al.
Publicado: (2022)

Human and mouse angiogenins: Emerging insights and potential opportunities
por: Sultana, Mst. Farzana, et al.
Publicado: (2022)

Hepatocyte-Specific Triggering of Hepatic Stellate Cell Profibrotic Activation by Apoptotic Bodies: The Role of Hepatoma-Derived Growth Factor, HIV, and Ethanol
por: New-Aaron, Moses, et al.
Publicado: (2023)

Angiogenin Enhances Cell Migration by Regulating Stress Fiber Assembly and Focal Adhesion Dynamics
por: Wei, Saisai, et al.
Publicado: (2011)

L-mimosine and hypoxia can increase angiogenin production in dental pulp-derived cells
por: Janjić, Klara, et al.
Publicado: (2017)

Chemosensitization of prostate cancer stem cells in mice by angiogenin and plexin-B2 inhibitors
por: Li, Shuping, et al.
Publicado: (2020)

Structural and functional implications of positive selection at the primate angiogenin gene
por: Osorio, Daniel S, et al.
Publicado: (2007)

Angiogenin Levels and ANG Genotypes: Dysregulation in Amyotrophic Lateral Sclerosis
por: McLaughlin, Russell Lewis, et al.
Publicado: (2010)

Prostate cancer-derived angiogenin stimulates the invasion of prostate fibroblasts
por: Jones, Michelle L, et al.
Publicado: (2012)

Human angiogenin is a potent cytotoxin in the absence of ribonuclease inhibitor
por: Thomas, Sydney P., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_pu8g04alp9foc3249c0rd9tvhd