Variant allele frequency enrichment analysis in vitro reveals sonic hedgehog pathway to impede sustained temozolomide response in GBM

Neoplastic cells of Glioblastoma multiforme (GBM) may or may not show sustained response to temozolomide (TMZ) chemotherapy. We hypothesize that TMZ chemotherapy response in GBM is predetermined in its neoplastic clones via a specific set of mutations that alter relevant pathways. We describe exome-...

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Detalles Bibliográficos
Autores principales: Biswas, Nidhan K., Chandra, Vikas, Sarkar-Roy, Neeta, Das, Tapojyoti, Bhattacharya, Rabindra N., Tripathy, Laxmi N., Basu, Sunandan K., Kumar, Shantanu, Das, Subrata, Chatterjee, Ankita, Mukherjee, Ankur, Basu, Pryiadarshi, Maitra, Arindam, Chattopadhyay, Ansuman, Basu, Analabha, Dhara, Surajit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300501/
https://www.ncbi.nlm.nih.gov/pubmed/25604826
http://dx.doi.org/10.1038/srep07915

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