Intracellular CD24 disrupts the ARF–NPM interaction and enables mutational and viral oncogene-mediated p53 inactivation

CD24 is overexpressed in nearly 70% human cancers, whereas TP53 is the most frequently mutated tumour-suppressor gene that functions in a context-dependent manner. Here we show that both targeted mutation and short hairpin RNA (shRNA) silencing of CD24 retard the growth, progression and metastasis o...

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Detalles Bibliográficos
Autores principales: Wang, Lizhong, Liu, Runhua, Ye, Peiying, Wong, Chunshu, Chen, Guo-Yun, Zhou, Penghui, Sakabe, Kaoru, Zheng, Xincheng, Wu, Wei, Zhang, Peng, Jiang, Taijiao, Bassetti, Michael F., Jube, Sandro, Sun, Yi, Zhang, Yanping, Zheng, Pan, Liu, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300525/
https://www.ncbi.nlm.nih.gov/pubmed/25600590
http://dx.doi.org/10.1038/ncomms6909

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