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A dynamically coupled allosteric network underlies binding cooperativity in Src kinase

Protein tyrosine kinases are attractive drug targets because many human diseases are associated with the deregulation of kinase activity. However, how the catalytic kinase domain integrates different signals and switches from an active to an inactive conformation remains incompletely understood. Her...

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Detalles Bibliográficos
Autores principales: Foda, Zachariah H., Shan, Yibing, Kim, Eric T., Shaw, David E., Seeliger, Markus A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300553/
https://www.ncbi.nlm.nih.gov/pubmed/25600932
http://dx.doi.org/10.1038/ncomms6939

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