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Engineering synthetic antibody binders for allosteric inhibition of prolactin receptor signaling

BACKGROUND: Many receptors function by binding to multiple ligands, each eliciting a distinct biological output. The extracellular domain of the human prolactin receptor (hPRL-R) uses an identical epitope to bind to both prolactin (hPRL) and growth hormone (hGH), yet little is known about how each h...

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Detalles Bibliográficos
Autores principales:	Rizk, Shahir S, Kouadio, Jean-Louis K, Szymborska, Anna, Duguid, Erica M, Mukherjee, Somnath, Zheng, Jiamao, Clevenger, Charles V, Kossiakoff, Anthony A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Short Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300558/ https://www.ncbi.nlm.nih.gov/pubmed/25589173 http://dx.doi.org/10.1186/s12964-014-0080-8

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