TNFR1-JNK signaling is the shared pathway of neuroinflammation and neurovascular damage after LPS-sensitized hypoxic-ischemic injury in the immature brain

BACKGROUND: Hypoxic-ischemia (HI) and inflammation are the two major pathogenic mechanisms of brain injury in very preterm infants. The neurovascular unit is the major target of HI injury in the immature brain. Systemic inflammation may worsen HI by up-regulating neuroinflammation and disrupting the...

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Detalles Bibliográficos
Autores principales: Wang, Lan-Wan, Chang, Ying-Chao, Chen, Shyi-Jou, Tseng, Chien-Hang, Tu, Yi-Fang, Liao, Nan-Shih, Huang, Chao-Ching, Ho, Chien-Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300587/
https://www.ncbi.nlm.nih.gov/pubmed/25540015
http://dx.doi.org/10.1186/s12974-014-0215-2

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