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Evaluation of relationship between breast cancer and migraine

BACKGROUND: Frequency of migraine changes at different times of a woman's reproductive cycle because of fluctuation of estrogen levels. Breast cancer has also a link with hormonal changes. Given this fact that both migraine and breast cancer are affected by estrogen, the prevalence of migraine...

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Autores principales: Ghorbani, Abbas, Moradi, Azam, Gookizadeh, Abbas, Jokar, Saman, Sonbolestan, Seyed Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300591/
https://www.ncbi.nlm.nih.gov/pubmed/25625120
http://dx.doi.org/10.4103/2277-9175.148297
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author Ghorbani, Abbas
Moradi, Azam
Gookizadeh, Abbas
Jokar, Saman
Sonbolestan, Seyed Ali
author_facet Ghorbani, Abbas
Moradi, Azam
Gookizadeh, Abbas
Jokar, Saman
Sonbolestan, Seyed Ali
author_sort Ghorbani, Abbas
collection PubMed
description BACKGROUND: Frequency of migraine changes at different times of a woman's reproductive cycle because of fluctuation of estrogen levels. Breast cancer has also a link with hormonal changes. Given this fact that both migraine and breast cancer are affected by estrogen, the prevalence of migraine may be different in breast cancer patients compared to the normal population. MATERIALS AND METHODS: In this case–control study, two groups of women with and without breast cancer were compared regarding the prevalence of migraine. Each group consisted of 400 women. The diagnosis of different types of headache was made based on The International Headache Society (IHS) guidelines. Type of headache, type and receptor status of breast cancer, as well as history of taking hormonal medications was recorded. Independent t-test and Chi-square tests were used for data analysis. RESULTS: Relative frequency of migraine headache in the normal woman was 38% compared to 19% in the breast cancer group (P < 0.0001). Tension headache was also significantly more prevalent in the normal group (P < 0.001). The frequency of migraine was significantly lower in estrogen receptor (ER)+/progesterone receptor (PR)− women compared to ER−/PR+ (26 and 43 women, respectively; P = 0.04); however, this difference was not significant for tension headache (P = 0.68). CONCLUSION: This study confirmed the lower frequency of migraine, as well as tension headache, in breast cancer sufferers. This could be contributed to several non-hormonal factors, such as a history of long term use of nonsteroidal anti-inflammatory drugs (NSAIDs), and hormonal factors, although only migraine showed a strong link with hormone status.
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spelling pubmed-43005912015-01-26 Evaluation of relationship between breast cancer and migraine Ghorbani, Abbas Moradi, Azam Gookizadeh, Abbas Jokar, Saman Sonbolestan, Seyed Ali Adv Biomed Res Original Article BACKGROUND: Frequency of migraine changes at different times of a woman's reproductive cycle because of fluctuation of estrogen levels. Breast cancer has also a link with hormonal changes. Given this fact that both migraine and breast cancer are affected by estrogen, the prevalence of migraine may be different in breast cancer patients compared to the normal population. MATERIALS AND METHODS: In this case–control study, two groups of women with and without breast cancer were compared regarding the prevalence of migraine. Each group consisted of 400 women. The diagnosis of different types of headache was made based on The International Headache Society (IHS) guidelines. Type of headache, type and receptor status of breast cancer, as well as history of taking hormonal medications was recorded. Independent t-test and Chi-square tests were used for data analysis. RESULTS: Relative frequency of migraine headache in the normal woman was 38% compared to 19% in the breast cancer group (P < 0.0001). Tension headache was also significantly more prevalent in the normal group (P < 0.001). The frequency of migraine was significantly lower in estrogen receptor (ER)+/progesterone receptor (PR)− women compared to ER−/PR+ (26 and 43 women, respectively; P = 0.04); however, this difference was not significant for tension headache (P = 0.68). CONCLUSION: This study confirmed the lower frequency of migraine, as well as tension headache, in breast cancer sufferers. This could be contributed to several non-hormonal factors, such as a history of long term use of nonsteroidal anti-inflammatory drugs (NSAIDs), and hormonal factors, although only migraine showed a strong link with hormone status. Medknow Publications & Media Pvt Ltd 2015-01-06 /pmc/articles/PMC4300591/ /pubmed/25625120 http://dx.doi.org/10.4103/2277-9175.148297 Text en Copyright: © 2015 Ghorbani http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Original Article
Ghorbani, Abbas
Moradi, Azam
Gookizadeh, Abbas
Jokar, Saman
Sonbolestan, Seyed Ali
Evaluation of relationship between breast cancer and migraine
title Evaluation of relationship between breast cancer and migraine
title_full Evaluation of relationship between breast cancer and migraine
title_fullStr Evaluation of relationship between breast cancer and migraine
title_full_unstemmed Evaluation of relationship between breast cancer and migraine
title_short Evaluation of relationship between breast cancer and migraine
title_sort evaluation of relationship between breast cancer and migraine
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300591/
https://www.ncbi.nlm.nih.gov/pubmed/25625120
http://dx.doi.org/10.4103/2277-9175.148297
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