Cargando…
Spinal cord ependymomas and the appearance of other de novo tumors: a systematic review
INTRODUCTION: Ependymomas are rare glial tumors of the brain representing less than 5% of brain tumors. However, spinal cord ependymomas in adults account for over 60% of all ependymomas including those arising from the filum terminale and only 40% are intracranial. Reports of the appearance of anot...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300603/ https://www.ncbi.nlm.nih.gov/pubmed/25519213 http://dx.doi.org/10.1186/1752-1947-8-438 |
_version_ | 1782353549134397440 |
---|---|
author | Fotakopoulos, George Vagkopoulos, Konstantinos Gatos, Charalabos Kotlia, Polikceni Brotis, Alexandros |
author_facet | Fotakopoulos, George Vagkopoulos, Konstantinos Gatos, Charalabos Kotlia, Polikceni Brotis, Alexandros |
author_sort | Fotakopoulos, George |
collection | PubMed |
description | INTRODUCTION: Ependymomas are rare glial tumors of the brain representing less than 5% of brain tumors. However, spinal cord ependymomas in adults account for over 60% of all ependymomas including those arising from the filum terminale and only 40% are intracranial. Reports of the appearance of another neoplasia at a different location in patients with spinal ependymoma are scarce. METHODS: We searched PubMed for studies related to spinal cord ependymomas published over the last 30 years (from January 1984) and retrieved 1197. RESULTS: We identified only two studies that met our criteria and we found an incidence of 9% of secondary neoplasias after treatment for spinal ependymoma. The neoplasms were diagnosed from 2 months to 20 years after patients underwent surgery for intraspinal ependymoma. These included pancreatic cancer, prostate cancer, Hodgkin lymphoma, intracranial meningioma, mucin-producing pulmonary adenocarcinoma, gastric cancer and astrocytoma. CONCLUSIONS: The genetic abnormalities affecting patients with spinal ependymomas may indicate a predisposition to the development of secondary cancers or a general failure of the repairing mechanism in their DNA. The unaffected survival rates in those individuals permit for a long period the accumulation of different mutations on the genome and thus the appearance of a second cancer. However, more studies are needed, particularly in young patients with high survival rates. |
format | Online Article Text |
id | pubmed-4300603 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-43006032015-01-22 Spinal cord ependymomas and the appearance of other de novo tumors: a systematic review Fotakopoulos, George Vagkopoulos, Konstantinos Gatos, Charalabos Kotlia, Polikceni Brotis, Alexandros J Med Case Rep Research Article INTRODUCTION: Ependymomas are rare glial tumors of the brain representing less than 5% of brain tumors. However, spinal cord ependymomas in adults account for over 60% of all ependymomas including those arising from the filum terminale and only 40% are intracranial. Reports of the appearance of another neoplasia at a different location in patients with spinal ependymoma are scarce. METHODS: We searched PubMed for studies related to spinal cord ependymomas published over the last 30 years (from January 1984) and retrieved 1197. RESULTS: We identified only two studies that met our criteria and we found an incidence of 9% of secondary neoplasias after treatment for spinal ependymoma. The neoplasms were diagnosed from 2 months to 20 years after patients underwent surgery for intraspinal ependymoma. These included pancreatic cancer, prostate cancer, Hodgkin lymphoma, intracranial meningioma, mucin-producing pulmonary adenocarcinoma, gastric cancer and astrocytoma. CONCLUSIONS: The genetic abnormalities affecting patients with spinal ependymomas may indicate a predisposition to the development of secondary cancers or a general failure of the repairing mechanism in their DNA. The unaffected survival rates in those individuals permit for a long period the accumulation of different mutations on the genome and thus the appearance of a second cancer. However, more studies are needed, particularly in young patients with high survival rates. BioMed Central 2014-12-18 /pmc/articles/PMC4300603/ /pubmed/25519213 http://dx.doi.org/10.1186/1752-1947-8-438 Text en © Fotakopoulos et al.; licensee BioMed Central. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Fotakopoulos, George Vagkopoulos, Konstantinos Gatos, Charalabos Kotlia, Polikceni Brotis, Alexandros Spinal cord ependymomas and the appearance of other de novo tumors: a systematic review |
title | Spinal cord ependymomas and the appearance of other de novo tumors: a systematic review |
title_full | Spinal cord ependymomas and the appearance of other de novo tumors: a systematic review |
title_fullStr | Spinal cord ependymomas and the appearance of other de novo tumors: a systematic review |
title_full_unstemmed | Spinal cord ependymomas and the appearance of other de novo tumors: a systematic review |
title_short | Spinal cord ependymomas and the appearance of other de novo tumors: a systematic review |
title_sort | spinal cord ependymomas and the appearance of other de novo tumors: a systematic review |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300603/ https://www.ncbi.nlm.nih.gov/pubmed/25519213 http://dx.doi.org/10.1186/1752-1947-8-438 |
work_keys_str_mv | AT fotakopoulosgeorge spinalcordependymomasandtheappearanceofotherdenovotumorsasystematicreview AT vagkopouloskonstantinos spinalcordependymomasandtheappearanceofotherdenovotumorsasystematicreview AT gatoscharalabos spinalcordependymomasandtheappearanceofotherdenovotumorsasystematicreview AT kotliapolikceni spinalcordependymomasandtheappearanceofotherdenovotumorsasystematicreview AT brotisalexandros spinalcordependymomasandtheappearanceofotherdenovotumorsasystematicreview |