Identification of novel fusion genes in lung cancer using breakpoint assembly of transcriptome sequencing data

Genomic translocation events frequently underlie cancer development through generation of gene fusions with oncogenic properties. Identification of such fusion transcripts by transcriptome sequencing might help to discover new potential therapeutic targets. We developed TRUP (Tumor-specimen suited R...

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Detalles Bibliográficos
Autores principales: Fernandez-Cuesta, Lynnette, Sun, Ruping, Menon, Roopika, George, Julie, Lorenz, Susanne, Meza-Zepeda, Leonardo A, Peifer, Martin, Plenker, Dennis, Heuckmann, Johannes M, Leenders, Frauke, Zander, Thomas, Dahmen, Ilona, Koker, Mirjam, Schöttle, Jakob, Ullrich, Roland T, Altmüller, Janine, Becker, Christian, Nürnberg, Peter, Seidel, Henrik, Böhm, Diana, Göke, Friederike, Ansén, Sascha, Russell, Prudence A, Wright, Gavin M, Wainer, Zoe, Solomon, Benjamin, Petersen, Iver, Clement, Joachim H, Sänger, Jörg, Brustugun, Odd-Terje, Helland, Åslaug, Solberg, Steinar, Lund-Iversen, Marius, Buettner, Reinhard, Wolf, Jürgen, Brambilla, Elisabeth, Vingron, Martin, Perner, Sven, Haas, Stefan A, Thomas, Roman K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300615/
https://www.ncbi.nlm.nih.gov/pubmed/25650807
http://dx.doi.org/10.1186/s13059-014-0558-0

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