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The extracellular N-terminal domain of G-protein coupled receptor 83 regulates signaling properties and is an intramolecular inverse agonist

BACKGROUND: Recently, the orphan G-protein coupled receptor 83 (GPR83) was identified as a new participant in body weight regulation. This receptor is highly expressed in the hypothalamic arcuate nucleus and is regulated in response to nutrient availability. Gpr83 knock-out mice are protected from d...

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Detalles Bibliográficos
Autores principales:	Müller, Anne, Leinweber, Brinja, Fischer, Jana, Müller, Timo D, Grüters, Annette, Tschöp, Matthias H, Knäuper, Vera, Biebermann, Heike, Kleinau, Gunnar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Short Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300838/ https://www.ncbi.nlm.nih.gov/pubmed/25516095 http://dx.doi.org/10.1186/1756-0500-7-913

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