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The Fornix in Mild Cognitive Impairment and Alzheimer’s Disease

The fornix is an integral white matter bundle located in the medial diencephalon and is part of the limbic structures. It serves a vital role in memory functions and as such has become the subject of recent research emphasis in Alzheimer’s disease (AD) and mild cognitive impairment (MCI). As the cha...

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Autores principales: Nowrangi, Milap A., Rosenberg, Paul B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301006/
https://www.ncbi.nlm.nih.gov/pubmed/25653617
http://dx.doi.org/10.3389/fnagi.2015.00001
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author Nowrangi, Milap A.
Rosenberg, Paul B.
author_facet Nowrangi, Milap A.
Rosenberg, Paul B.
author_sort Nowrangi, Milap A.
collection PubMed
description The fornix is an integral white matter bundle located in the medial diencephalon and is part of the limbic structures. It serves a vital role in memory functions and as such has become the subject of recent research emphasis in Alzheimer’s disease (AD) and mild cognitive impairment (MCI). As the characteristic pathological processes of AD progress, structural and functional changes to the medial temporal lobes and other regions become evident years before clinical symptoms are present. Though gray matter atrophy has been the most studied, degradation of white matter structures especially the fornix may precede these and has become detectable with use of diffusion tensor imaging (DTI) and other complimentary imaging techniques. Recent research utilizing DTI measurement of the fornix has shown good discriminability of diagnostic groups, particularly early and preclinical, as well as predictive power for incident MCI and AD. Stimulating and modulating fornix function by the way of DBS has been an exciting new area as pharmacological therapeutics has been slow to develop.
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spelling pubmed-43010062015-02-04 The Fornix in Mild Cognitive Impairment and Alzheimer’s Disease Nowrangi, Milap A. Rosenberg, Paul B. Front Aging Neurosci Neuroscience The fornix is an integral white matter bundle located in the medial diencephalon and is part of the limbic structures. It serves a vital role in memory functions and as such has become the subject of recent research emphasis in Alzheimer’s disease (AD) and mild cognitive impairment (MCI). As the characteristic pathological processes of AD progress, structural and functional changes to the medial temporal lobes and other regions become evident years before clinical symptoms are present. Though gray matter atrophy has been the most studied, degradation of white matter structures especially the fornix may precede these and has become detectable with use of diffusion tensor imaging (DTI) and other complimentary imaging techniques. Recent research utilizing DTI measurement of the fornix has shown good discriminability of diagnostic groups, particularly early and preclinical, as well as predictive power for incident MCI and AD. Stimulating and modulating fornix function by the way of DBS has been an exciting new area as pharmacological therapeutics has been slow to develop. Frontiers Media S.A. 2015-01-21 /pmc/articles/PMC4301006/ /pubmed/25653617 http://dx.doi.org/10.3389/fnagi.2015.00001 Text en Copyright © 2015 Nowrangi and Rosenberg. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Nowrangi, Milap A.
Rosenberg, Paul B.
The Fornix in Mild Cognitive Impairment and Alzheimer’s Disease
title The Fornix in Mild Cognitive Impairment and Alzheimer’s Disease
title_full The Fornix in Mild Cognitive Impairment and Alzheimer’s Disease
title_fullStr The Fornix in Mild Cognitive Impairment and Alzheimer’s Disease
title_full_unstemmed The Fornix in Mild Cognitive Impairment and Alzheimer’s Disease
title_short The Fornix in Mild Cognitive Impairment and Alzheimer’s Disease
title_sort fornix in mild cognitive impairment and alzheimer’s disease
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301006/
https://www.ncbi.nlm.nih.gov/pubmed/25653617
http://dx.doi.org/10.3389/fnagi.2015.00001
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