Cholate-Based Synthesis of Size-Tunable Cage Compounds

[Image: see text] We describe cholate-based cage amphiphiles with a unique architecture that combines elements of structural rigidity and flexibility. The cage compounds are built by extending and bridging three polar chains underneath the concave steroid rings of cholate and capping with another ri...

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Autores principales: Peng, Lingling, Mo, Fanyang, Zhang, Qinghai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301076/
https://www.ncbi.nlm.nih.gov/pubmed/25536149
http://dx.doi.org/10.1021/jo5023734
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author Peng, Lingling
Mo, Fanyang
Zhang, Qinghai
author_facet Peng, Lingling
Mo, Fanyang
Zhang, Qinghai
author_sort Peng, Lingling
collection PubMed
description [Image: see text] We describe cholate-based cage amphiphiles with a unique architecture that combines elements of structural rigidity and flexibility. The cage compounds are built by extending and bridging three polar chains underneath the concave steroid rings of cholate and capping with another rigid, symmetrically trifunctionalized cyanuric acid moiety. The connecting chains are varied to include, for instance, oligo(ethylene glycol) or chains containing 1,2,3-triazole units to present flexibility in the chemical and structural space and potentially deliver functional molecules for molecular recognition applications.
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spelling pubmed-43010762015-12-23 Cholate-Based Synthesis of Size-Tunable Cage Compounds Peng, Lingling Mo, Fanyang Zhang, Qinghai J Org Chem [Image: see text] We describe cholate-based cage amphiphiles with a unique architecture that combines elements of structural rigidity and flexibility. The cage compounds are built by extending and bridging three polar chains underneath the concave steroid rings of cholate and capping with another rigid, symmetrically trifunctionalized cyanuric acid moiety. The connecting chains are varied to include, for instance, oligo(ethylene glycol) or chains containing 1,2,3-triazole units to present flexibility in the chemical and structural space and potentially deliver functional molecules for molecular recognition applications. American Chemical Society 2014-12-23 2015-01-16 /pmc/articles/PMC4301076/ /pubmed/25536149 http://dx.doi.org/10.1021/jo5023734 Text en Copyright © 2014 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Peng, Lingling
Mo, Fanyang
Zhang, Qinghai
Cholate-Based Synthesis of Size-Tunable Cage Compounds
title Cholate-Based Synthesis of Size-Tunable Cage Compounds
title_full Cholate-Based Synthesis of Size-Tunable Cage Compounds
title_fullStr Cholate-Based Synthesis of Size-Tunable Cage Compounds
title_full_unstemmed Cholate-Based Synthesis of Size-Tunable Cage Compounds
title_short Cholate-Based Synthesis of Size-Tunable Cage Compounds
title_sort cholate-based synthesis of size-tunable cage compounds
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301076/
https://www.ncbi.nlm.nih.gov/pubmed/25536149
http://dx.doi.org/10.1021/jo5023734
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AT mofanyang cholatebasedsynthesisofsizetunablecagecompounds
AT zhangqinghai cholatebasedsynthesisofsizetunablecagecompounds

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