Regioselective Gold-Catalyzed Oxidative C–N Bond Formation

[Image: see text] A novel protocol for the regioselective intermolecular amination of various arenes has been developed. By using an I(III) oxidant in the presence of a Au(I) catalyst, a direct and novel route for regioselectively accessing a variety of substituted aniline moieties has been achieved...

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Detalles Bibliográficos
Autores principales: Marchetti, Louis, Kantak, Abhishek, Davis, Riley, DeBoef, Brenton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301077/
https://www.ncbi.nlm.nih.gov/pubmed/25539392
http://dx.doi.org/10.1021/ol5034805
Descripción
Sumario:[Image: see text] A novel protocol for the regioselective intermolecular amination of various arenes has been developed. By using an I(III) oxidant in the presence of a Au(I) catalyst, a direct and novel route for regioselectively accessing a variety of substituted aniline moieties has been achieved with yields as high as 90%. Mechanistic insight suggests that regioselectivity can be predicted based on electrophilic aromatic metalation patterns.

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