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DFGmodel: Predicting Protein Kinase Structures in Inactive States for Structure-Based Discovery of Type-II Inhibitors

[Image: see text] Protein kinases exist in equilibrium of active and inactive states, in which the aspartate-phenylalanine-glycine motif in the catalytic domain undergoes conformational changes that are required for function. Drugs targeting protein kinases typically bind the primary ATP-binding sit...

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Detalles Bibliográficos
Autores principales:	Ung, Peter Man-Un, Schlessinger, Avner
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301084/ https://www.ncbi.nlm.nih.gov/pubmed/25420233 http://dx.doi.org/10.1021/cb500696t

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