Mild Palladium-Catalyzed Cyanation of (Hetero)aryl Halides and Triflates in Aqueous Media

[Image: see text] A mild, efficient, and low-temperature palladium-catalyzed cyanation of (hetero)aryl halides and triflates is reported. Previous palladium-catalyzed cyanations of (hetero)aryl halides have required higher temperatures to achieve good catalytic activity. This current reaction allows...

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Autores principales: Cohen, Daniel T., Buchwald, Stephen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301087/
https://www.ncbi.nlm.nih.gov/pubmed/25555140
http://dx.doi.org/10.1021/ol5032359
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author Cohen, Daniel T.
Buchwald, Stephen L.
author_facet Cohen, Daniel T.
Buchwald, Stephen L.
author_sort Cohen, Daniel T.
collection PubMed
description [Image: see text] A mild, efficient, and low-temperature palladium-catalyzed cyanation of (hetero)aryl halides and triflates is reported. Previous palladium-catalyzed cyanations of (hetero)aryl halides have required higher temperatures to achieve good catalytic activity. This current reaction allows the cyanation of a general scope of (hetero)aryl halides and triflates at 2–5 mol % catalyst loadings with temperatures ranging from rt to 40 °C. This mild method was applied to the synthesis of lersivirine, a reverse transcriptase inhibitor.
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spelling pubmed-43010872016-01-02 Mild Palladium-Catalyzed Cyanation of (Hetero)aryl Halides and Triflates in Aqueous Media Cohen, Daniel T. Buchwald, Stephen L. Org Lett [Image: see text] A mild, efficient, and low-temperature palladium-catalyzed cyanation of (hetero)aryl halides and triflates is reported. Previous palladium-catalyzed cyanations of (hetero)aryl halides have required higher temperatures to achieve good catalytic activity. This current reaction allows the cyanation of a general scope of (hetero)aryl halides and triflates at 2–5 mol % catalyst loadings with temperatures ranging from rt to 40 °C. This mild method was applied to the synthesis of lersivirine, a reverse transcriptase inhibitor. American Chemical Society 2015-01-02 2015-01-16 /pmc/articles/PMC4301087/ /pubmed/25555140 http://dx.doi.org/10.1021/ol5032359 Text en Copyright © 2015 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Cohen, Daniel T.
Buchwald, Stephen L.
Mild Palladium-Catalyzed Cyanation of (Hetero)aryl Halides and Triflates in Aqueous Media
title Mild Palladium-Catalyzed Cyanation of (Hetero)aryl Halides and Triflates in Aqueous Media
title_full Mild Palladium-Catalyzed Cyanation of (Hetero)aryl Halides and Triflates in Aqueous Media
title_fullStr Mild Palladium-Catalyzed Cyanation of (Hetero)aryl Halides and Triflates in Aqueous Media
title_full_unstemmed Mild Palladium-Catalyzed Cyanation of (Hetero)aryl Halides and Triflates in Aqueous Media
title_short Mild Palladium-Catalyzed Cyanation of (Hetero)aryl Halides and Triflates in Aqueous Media
title_sort mild palladium-catalyzed cyanation of (hetero)aryl halides and triflates in aqueous media
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301087/
https://www.ncbi.nlm.nih.gov/pubmed/25555140
http://dx.doi.org/10.1021/ol5032359
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