The inhibitory effect of Acyclovir loaded nano-niosomes against herpes simplex virus type-1 in cell culture

Background: Wide distribution and low half-life of acyclovir has led to a high dose consumption of the drug. Recent studies have shown that encapsulation of acyclovir in nano-carriers can increase effectiveness and decrease its side effects. We investigated the inhibitory effect of acyclovir loaded...

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Autores principales: Monavari, Seyed Hamidreza, Mirzaei parsa, Mohammad Javad, Bolouri, Bahram, Ebrahimi, Soltan Ahmed, Ataei-pirkooh, Angila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iran University of Medical Sciences 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301255/
https://www.ncbi.nlm.nih.gov/pubmed/25664300
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author Monavari, Seyed Hamidreza
Mirzaei parsa, Mohammad Javad
Bolouri, Bahram
Ebrahimi, Soltan Ahmed
Ataei-pirkooh, Angila
author_facet Monavari, Seyed Hamidreza
Mirzaei parsa, Mohammad Javad
Bolouri, Bahram
Ebrahimi, Soltan Ahmed
Ataei-pirkooh, Angila
author_sort Monavari, Seyed Hamidreza
collection PubMed
description Background: Wide distribution and low half-life of acyclovir has led to a high dose consumption of the drug. Recent studies have shown that encapsulation of acyclovir in nano-carriers can increase effectiveness and decrease its side effects. We investigated the inhibitory effect of acyclovir loaded nano-niosomes against herpes simplex virus type-1 (HSV-1) in cell culture. Methods: In-vitro cytotoxicity study of empty niosomes (E-N), acyclovir loaded niosomes (ACV-N) and ACV as a free drug against HeLa cell line was performed by MTT assay and the viral titers was tested by TCID50 assay. Results: The results indicated that a significant higher antiviral activity for acyclovir loaded nano-niosomes of about 3 times in comparison with free drug. Conclusion: The results of this study revealed ACV-N have a higher antiviral activity compared with free drug; it could be a suitable carrier for delivery of acyclovir in the treatment of HSV-1 infections.
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spelling pubmed-43012552015-02-06 The inhibitory effect of Acyclovir loaded nano-niosomes against herpes simplex virus type-1 in cell culture Monavari, Seyed Hamidreza Mirzaei parsa, Mohammad Javad Bolouri, Bahram Ebrahimi, Soltan Ahmed Ataei-pirkooh, Angila Med J Islam Repub Iran Original Article Background: Wide distribution and low half-life of acyclovir has led to a high dose consumption of the drug. Recent studies have shown that encapsulation of acyclovir in nano-carriers can increase effectiveness and decrease its side effects. We investigated the inhibitory effect of acyclovir loaded nano-niosomes against herpes simplex virus type-1 (HSV-1) in cell culture. Methods: In-vitro cytotoxicity study of empty niosomes (E-N), acyclovir loaded niosomes (ACV-N) and ACV as a free drug against HeLa cell line was performed by MTT assay and the viral titers was tested by TCID50 assay. Results: The results indicated that a significant higher antiviral activity for acyclovir loaded nano-niosomes of about 3 times in comparison with free drug. Conclusion: The results of this study revealed ACV-N have a higher antiviral activity compared with free drug; it could be a suitable carrier for delivery of acyclovir in the treatment of HSV-1 infections. Iran University of Medical Sciences 2014-09-17 /pmc/articles/PMC4301255/ /pubmed/25664300 Text en © 2014 Iran University of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution NonCommercial 3.0 License (CC BY-NC 3.0), which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Original Article
Monavari, Seyed Hamidreza
Mirzaei parsa, Mohammad Javad
Bolouri, Bahram
Ebrahimi, Soltan Ahmed
Ataei-pirkooh, Angila
The inhibitory effect of Acyclovir loaded nano-niosomes against herpes simplex virus type-1 in cell culture
title The inhibitory effect of Acyclovir loaded nano-niosomes against herpes simplex virus type-1 in cell culture
title_full The inhibitory effect of Acyclovir loaded nano-niosomes against herpes simplex virus type-1 in cell culture
title_fullStr The inhibitory effect of Acyclovir loaded nano-niosomes against herpes simplex virus type-1 in cell culture
title_full_unstemmed The inhibitory effect of Acyclovir loaded nano-niosomes against herpes simplex virus type-1 in cell culture
title_short The inhibitory effect of Acyclovir loaded nano-niosomes against herpes simplex virus type-1 in cell culture
title_sort inhibitory effect of acyclovir loaded nano-niosomes against herpes simplex virus type-1 in cell culture
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301255/
https://www.ncbi.nlm.nih.gov/pubmed/25664300
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