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Rapidly progressive primitive neuroectodermal tumor of the prostate: A case report and review of the literature

The present study reports a rare case of primitive neuroectodermal tumor (PNET) of the prostate. A 23-year-old male presented to Oita Medical Center (Oita, Japan) with the complaint of dysuria and anal pain. A large mass in the prostate and a number of swollen lymph nodes in the pelvic region were i...

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Autores principales: SHIBUYA, TADAMASA, MORI, KENICHI, SUMINO, YASUHIRO, SATO, FUMINORI, MIMATA, HIROMITSU
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301542/
https://www.ncbi.nlm.nih.gov/pubmed/25624891
http://dx.doi.org/10.3892/ol.2014.2731
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author SHIBUYA, TADAMASA
MORI, KENICHI
SUMINO, YASUHIRO
SATO, FUMINORI
MIMATA, HIROMITSU
author_facet SHIBUYA, TADAMASA
MORI, KENICHI
SUMINO, YASUHIRO
SATO, FUMINORI
MIMATA, HIROMITSU
author_sort SHIBUYA, TADAMASA
collection PubMed
description The present study reports a rare case of primitive neuroectodermal tumor (PNET) of the prostate. A 23-year-old male presented to Oita Medical Center (Oita, Japan) with the complaint of dysuria and anal pain. A large mass in the prostate and a number of swollen lymph nodes in the pelvic region were identified by a computed tomography scan and magnetic resonance imaging. The patient was, thus, admitted to Oita University Hospital (Yufu, Japan), where a biopsy of the prostate gland was performed. Histological analysis revealed small round cells that were positive for MIC-2 expression and fluorescent in situ hybridization analysis detected a translocation involving Ewing sarcoma breakpoint region 1 at chromosome 22q12. Thus, a diagnosis of PNET of the prostate was established. Systemic chemotherapy was the selected treatment, however, a poor response was obtained. The patient succumbed approximately four months after the initial onset of symptoms. PNET of the prostate has been reported in eight cases worldwide; in comparison, the present case exhibited the most unsatisfactory outcome.
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spelling pubmed-43015422015-01-26 Rapidly progressive primitive neuroectodermal tumor of the prostate: A case report and review of the literature SHIBUYA, TADAMASA MORI, KENICHI SUMINO, YASUHIRO SATO, FUMINORI MIMATA, HIROMITSU Oncol Lett Articles The present study reports a rare case of primitive neuroectodermal tumor (PNET) of the prostate. A 23-year-old male presented to Oita Medical Center (Oita, Japan) with the complaint of dysuria and anal pain. A large mass in the prostate and a number of swollen lymph nodes in the pelvic region were identified by a computed tomography scan and magnetic resonance imaging. The patient was, thus, admitted to Oita University Hospital (Yufu, Japan), where a biopsy of the prostate gland was performed. Histological analysis revealed small round cells that were positive for MIC-2 expression and fluorescent in situ hybridization analysis detected a translocation involving Ewing sarcoma breakpoint region 1 at chromosome 22q12. Thus, a diagnosis of PNET of the prostate was established. Systemic chemotherapy was the selected treatment, however, a poor response was obtained. The patient succumbed approximately four months after the initial onset of symptoms. PNET of the prostate has been reported in eight cases worldwide; in comparison, the present case exhibited the most unsatisfactory outcome. D.A. Spandidos 2015-02 2014-11-24 /pmc/articles/PMC4301542/ /pubmed/25624891 http://dx.doi.org/10.3892/ol.2014.2731 Text en Copyright © 2015, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
SHIBUYA, TADAMASA
MORI, KENICHI
SUMINO, YASUHIRO
SATO, FUMINORI
MIMATA, HIROMITSU
Rapidly progressive primitive neuroectodermal tumor of the prostate: A case report and review of the literature
title Rapidly progressive primitive neuroectodermal tumor of the prostate: A case report and review of the literature
title_full Rapidly progressive primitive neuroectodermal tumor of the prostate: A case report and review of the literature
title_fullStr Rapidly progressive primitive neuroectodermal tumor of the prostate: A case report and review of the literature
title_full_unstemmed Rapidly progressive primitive neuroectodermal tumor of the prostate: A case report and review of the literature
title_short Rapidly progressive primitive neuroectodermal tumor of the prostate: A case report and review of the literature
title_sort rapidly progressive primitive neuroectodermal tumor of the prostate: a case report and review of the literature
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301542/
https://www.ncbi.nlm.nih.gov/pubmed/25624891
http://dx.doi.org/10.3892/ol.2014.2731
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