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Immunohistochemical staining of tumor necrosis factor-α and interleukin-10 in benign and malignant ovarian neoplasms
Ovarian cancer is the ninth most common malignancy and the fifth leading cause of cancer death in women in the USA. The majority of malignant tumors of the ovary are diagnosed at an advanced stage, making it the most fatal gynecological cancer. The aim of the current study was to determine whether t...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301559/ https://www.ncbi.nlm.nih.gov/pubmed/25624918 http://dx.doi.org/10.3892/ol.2014.2781 |
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author | JAMMAL, MILLENA PRATA DA SILVA, ALLISON ARAÚJO FILHO, AGRIMALDO MARTINS DE CASTRO CÔBO, ELIÂNGELA ADAD, SHEILA JORGE MURTA, EDDIE FERNANDO CANDIDO NOMELINI, ROSEKEILA SIMÕES |
author_facet | JAMMAL, MILLENA PRATA DA SILVA, ALLISON ARAÚJO FILHO, AGRIMALDO MARTINS DE CASTRO CÔBO, ELIÂNGELA ADAD, SHEILA JORGE MURTA, EDDIE FERNANDO CANDIDO NOMELINI, ROSEKEILA SIMÕES |
author_sort | JAMMAL, MILLENA PRATA |
collection | PubMed |
description | Ovarian cancer is the ninth most common malignancy and the fifth leading cause of cancer death in women in the USA. The majority of malignant tumors of the ovary are diagnosed at an advanced stage, making it the most fatal gynecological cancer. The aim of the current study was to determine whether there are differences in immunohistochemical tissue staining of cytokine tumor necrosis factor-α (TNF-α) and interleukin-10 (IL-10) between benign tumors and malignant primary ovarian cancer. In total, 28 patients undergoing surgery for ovarian cysts were evaluated, and a diagnosis of benign neoplasm (n=14) or malignant neoplasm (n=14) was determined. An immunohistochemical study of histological sections of ovarian tumors was conducted. The results were analyzed using Fisher’s exact test, with P<0.05 indicating a statistically significant difference. Immunohistochemical staining of IL-10 was increased in malignant tumors compared with benign tumors (P=0.0128). For TNF-α, the immunohistochemical staining was more intense in malignant neoplasms, however, a statistically significant difference was not observed. These results indicate that the analysis of cytokines may be useful as a potential tissue marker of ovarian malignancy. |
format | Online Article Text |
id | pubmed-4301559 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-43015592015-01-26 Immunohistochemical staining of tumor necrosis factor-α and interleukin-10 in benign and malignant ovarian neoplasms JAMMAL, MILLENA PRATA DA SILVA, ALLISON ARAÚJO FILHO, AGRIMALDO MARTINS DE CASTRO CÔBO, ELIÂNGELA ADAD, SHEILA JORGE MURTA, EDDIE FERNANDO CANDIDO NOMELINI, ROSEKEILA SIMÕES Oncol Lett Articles Ovarian cancer is the ninth most common malignancy and the fifth leading cause of cancer death in women in the USA. The majority of malignant tumors of the ovary are diagnosed at an advanced stage, making it the most fatal gynecological cancer. The aim of the current study was to determine whether there are differences in immunohistochemical tissue staining of cytokine tumor necrosis factor-α (TNF-α) and interleukin-10 (IL-10) between benign tumors and malignant primary ovarian cancer. In total, 28 patients undergoing surgery for ovarian cysts were evaluated, and a diagnosis of benign neoplasm (n=14) or malignant neoplasm (n=14) was determined. An immunohistochemical study of histological sections of ovarian tumors was conducted. The results were analyzed using Fisher’s exact test, with P<0.05 indicating a statistically significant difference. Immunohistochemical staining of IL-10 was increased in malignant tumors compared with benign tumors (P=0.0128). For TNF-α, the immunohistochemical staining was more intense in malignant neoplasms, however, a statistically significant difference was not observed. These results indicate that the analysis of cytokines may be useful as a potential tissue marker of ovarian malignancy. D.A. Spandidos 2015-02 2014-12-08 /pmc/articles/PMC4301559/ /pubmed/25624918 http://dx.doi.org/10.3892/ol.2014.2781 Text en Copyright © 2015, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Articles JAMMAL, MILLENA PRATA DA SILVA, ALLISON ARAÚJO FILHO, AGRIMALDO MARTINS DE CASTRO CÔBO, ELIÂNGELA ADAD, SHEILA JORGE MURTA, EDDIE FERNANDO CANDIDO NOMELINI, ROSEKEILA SIMÕES Immunohistochemical staining of tumor necrosis factor-α and interleukin-10 in benign and malignant ovarian neoplasms |
title | Immunohistochemical staining of tumor necrosis factor-α and interleukin-10 in benign and malignant ovarian neoplasms |
title_full | Immunohistochemical staining of tumor necrosis factor-α and interleukin-10 in benign and malignant ovarian neoplasms |
title_fullStr | Immunohistochemical staining of tumor necrosis factor-α and interleukin-10 in benign and malignant ovarian neoplasms |
title_full_unstemmed | Immunohistochemical staining of tumor necrosis factor-α and interleukin-10 in benign and malignant ovarian neoplasms |
title_short | Immunohistochemical staining of tumor necrosis factor-α and interleukin-10 in benign and malignant ovarian neoplasms |
title_sort | immunohistochemical staining of tumor necrosis factor-α and interleukin-10 in benign and malignant ovarian neoplasms |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301559/ https://www.ncbi.nlm.nih.gov/pubmed/25624918 http://dx.doi.org/10.3892/ol.2014.2781 |
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