Cargando…

Immunohistochemical staining of tumor necrosis factor-α and interleukin-10 in benign and malignant ovarian neoplasms

Ovarian cancer is the ninth most common malignancy and the fifth leading cause of cancer death in women in the USA. The majority of malignant tumors of the ovary are diagnosed at an advanced stage, making it the most fatal gynecological cancer. The aim of the current study was to determine whether t...

Descripción completa

Detalles Bibliográficos
Autores principales: JAMMAL, MILLENA PRATA, DA SILVA, ALLISON ARAÚJO, FILHO, AGRIMALDO MARTINS, DE CASTRO CÔBO, ELIÂNGELA, ADAD, SHEILA JORGE, MURTA, EDDIE FERNANDO CANDIDO, NOMELINI, ROSEKEILA SIMÕES
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301559/
https://www.ncbi.nlm.nih.gov/pubmed/25624918
http://dx.doi.org/10.3892/ol.2014.2781
_version_ 1782353667771334656
author JAMMAL, MILLENA PRATA
DA SILVA, ALLISON ARAÚJO
FILHO, AGRIMALDO MARTINS
DE CASTRO CÔBO, ELIÂNGELA
ADAD, SHEILA JORGE
MURTA, EDDIE FERNANDO CANDIDO
NOMELINI, ROSEKEILA SIMÕES
author_facet JAMMAL, MILLENA PRATA
DA SILVA, ALLISON ARAÚJO
FILHO, AGRIMALDO MARTINS
DE CASTRO CÔBO, ELIÂNGELA
ADAD, SHEILA JORGE
MURTA, EDDIE FERNANDO CANDIDO
NOMELINI, ROSEKEILA SIMÕES
author_sort JAMMAL, MILLENA PRATA
collection PubMed
description Ovarian cancer is the ninth most common malignancy and the fifth leading cause of cancer death in women in the USA. The majority of malignant tumors of the ovary are diagnosed at an advanced stage, making it the most fatal gynecological cancer. The aim of the current study was to determine whether there are differences in immunohistochemical tissue staining of cytokine tumor necrosis factor-α (TNF-α) and interleukin-10 (IL-10) between benign tumors and malignant primary ovarian cancer. In total, 28 patients undergoing surgery for ovarian cysts were evaluated, and a diagnosis of benign neoplasm (n=14) or malignant neoplasm (n=14) was determined. An immunohistochemical study of histological sections of ovarian tumors was conducted. The results were analyzed using Fisher’s exact test, with P<0.05 indicating a statistically significant difference. Immunohistochemical staining of IL-10 was increased in malignant tumors compared with benign tumors (P=0.0128). For TNF-α, the immunohistochemical staining was more intense in malignant neoplasms, however, a statistically significant difference was not observed. These results indicate that the analysis of cytokines may be useful as a potential tissue marker of ovarian malignancy.
format Online
Article
Text
id pubmed-4301559
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher D.A. Spandidos
record_format MEDLINE/PubMed
spelling pubmed-43015592015-01-26 Immunohistochemical staining of tumor necrosis factor-α and interleukin-10 in benign and malignant ovarian neoplasms JAMMAL, MILLENA PRATA DA SILVA, ALLISON ARAÚJO FILHO, AGRIMALDO MARTINS DE CASTRO CÔBO, ELIÂNGELA ADAD, SHEILA JORGE MURTA, EDDIE FERNANDO CANDIDO NOMELINI, ROSEKEILA SIMÕES Oncol Lett Articles Ovarian cancer is the ninth most common malignancy and the fifth leading cause of cancer death in women in the USA. The majority of malignant tumors of the ovary are diagnosed at an advanced stage, making it the most fatal gynecological cancer. The aim of the current study was to determine whether there are differences in immunohistochemical tissue staining of cytokine tumor necrosis factor-α (TNF-α) and interleukin-10 (IL-10) between benign tumors and malignant primary ovarian cancer. In total, 28 patients undergoing surgery for ovarian cysts were evaluated, and a diagnosis of benign neoplasm (n=14) or malignant neoplasm (n=14) was determined. An immunohistochemical study of histological sections of ovarian tumors was conducted. The results were analyzed using Fisher’s exact test, with P<0.05 indicating a statistically significant difference. Immunohistochemical staining of IL-10 was increased in malignant tumors compared with benign tumors (P=0.0128). For TNF-α, the immunohistochemical staining was more intense in malignant neoplasms, however, a statistically significant difference was not observed. These results indicate that the analysis of cytokines may be useful as a potential tissue marker of ovarian malignancy. D.A. Spandidos 2015-02 2014-12-08 /pmc/articles/PMC4301559/ /pubmed/25624918 http://dx.doi.org/10.3892/ol.2014.2781 Text en Copyright © 2015, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
JAMMAL, MILLENA PRATA
DA SILVA, ALLISON ARAÚJO
FILHO, AGRIMALDO MARTINS
DE CASTRO CÔBO, ELIÂNGELA
ADAD, SHEILA JORGE
MURTA, EDDIE FERNANDO CANDIDO
NOMELINI, ROSEKEILA SIMÕES
Immunohistochemical staining of tumor necrosis factor-α and interleukin-10 in benign and malignant ovarian neoplasms
title Immunohistochemical staining of tumor necrosis factor-α and interleukin-10 in benign and malignant ovarian neoplasms
title_full Immunohistochemical staining of tumor necrosis factor-α and interleukin-10 in benign and malignant ovarian neoplasms
title_fullStr Immunohistochemical staining of tumor necrosis factor-α and interleukin-10 in benign and malignant ovarian neoplasms
title_full_unstemmed Immunohistochemical staining of tumor necrosis factor-α and interleukin-10 in benign and malignant ovarian neoplasms
title_short Immunohistochemical staining of tumor necrosis factor-α and interleukin-10 in benign and malignant ovarian neoplasms
title_sort immunohistochemical staining of tumor necrosis factor-α and interleukin-10 in benign and malignant ovarian neoplasms
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301559/
https://www.ncbi.nlm.nih.gov/pubmed/25624918
http://dx.doi.org/10.3892/ol.2014.2781
work_keys_str_mv AT jammalmillenaprata immunohistochemicalstainingoftumornecrosisfactoraandinterleukin10inbenignandmalignantovarianneoplasms
AT dasilvaallisonaraujo immunohistochemicalstainingoftumornecrosisfactoraandinterleukin10inbenignandmalignantovarianneoplasms
AT filhoagrimaldomartins immunohistochemicalstainingoftumornecrosisfactoraandinterleukin10inbenignandmalignantovarianneoplasms
AT decastrocoboeliangela immunohistochemicalstainingoftumornecrosisfactoraandinterleukin10inbenignandmalignantovarianneoplasms
AT adadsheilajorge immunohistochemicalstainingoftumornecrosisfactoraandinterleukin10inbenignandmalignantovarianneoplasms
AT murtaeddiefernandocandido immunohistochemicalstainingoftumornecrosisfactoraandinterleukin10inbenignandmalignantovarianneoplasms
AT nomelinirosekeilasimoes immunohistochemicalstainingoftumornecrosisfactoraandinterleukin10inbenignandmalignantovarianneoplasms