A phase II clinical trial of 6-mercaptopurine (6MP) and methotrexate in patients with BRCA defective tumours: a study protocol

BACKGROUND: BRCA1 and BRCA2 genes are critical in homologous recombination DNA repair and have been implicated in familial breast and ovarian cancer tumorigenesis. Tumour cells with these mutations demonstrate increased sensitivity to cisplatin and poly (ADP-ribose) polymerase (PARP) inhibitors. 6MP...

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Detalles Bibliográficos
Autores principales: Nicum, Shibani, Roberts, Corran, Boyle, Lucy, Kopijasz, Sylwia, Gourley, Charlie, Hall, Marcia, Montes, Ana, Poole, Christopher, Collins, Linda, Schuh, Anna, Dutton, Susan J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301834/
https://www.ncbi.nlm.nih.gov/pubmed/25526776
http://dx.doi.org/10.1186/1471-2407-14-983

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301834/
https://www.ncbi.nlm.nih.gov/pubmed/25526776
http://dx.doi.org/10.1186/1471-2407-14-983

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