The Sirtuin-2 Inhibitor AK7 Is Neuroprotective in Models of Parkinson’s Disease but Not Amyotrophic Lateral Sclerosis and Cerebral Ischemia

Sirtuin deacetylases regulate diverse cellular pathways and influence disease processes. Our previous studies identified the brain-enriched sirtuin-2 (SIRT2) deacetylase as a potential drug target to counteract neurodegeneration. In the present study, we characterize SIRT2 inhibition activity of the...

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Detalles Bibliográficos
Autores principales: Chen, Xiqun, Wales, Pauline, Quinti, Luisa, Zuo, Fuxing, Moniot, Sébastien, Herisson, Fanny, Rauf, Nazifa Abdul, Wang, Hua, Silverman, Richard B., Ayata, Cenk, Maxwell, Michelle M., Steegborn, Clemens, Schwarzschild, Michael A., Outeiro, Tiago F., Kazantsev, Aleksey G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301865/
https://www.ncbi.nlm.nih.gov/pubmed/25608039
http://dx.doi.org/10.1371/journal.pone.0116919

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