WW Domains of the Yes-Kinase-Associated-Protein (YAP) Transcriptional Regulator Behave as Independent Units with Different Binding Preferences for PPxY Motif-Containing Ligands

YAP is a WW domain-containing effector of the Hippo tumor suppressor pathway, and the object of heightened interest as a potent oncogene and stemness factor. YAP has two major isoforms that differ in the number of WW domains they harbor. Elucidating the degree of co-operation between these WW domain...

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Detalles Bibliográficos
Autores principales: Iglesias-Bexiga, Manuel, Castillo, Francisco, Cobos, Eva S., Oka, Tsutomu, Sudol, Marius, Luque, Irene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301871/
https://www.ncbi.nlm.nih.gov/pubmed/25607641
http://dx.doi.org/10.1371/journal.pone.0113828

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301871/
https://www.ncbi.nlm.nih.gov/pubmed/25607641
http://dx.doi.org/10.1371/journal.pone.0113828

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