Cargando…

WW Domains of the Yes-Kinase-Associated-Protein (YAP) Transcriptional Regulator Behave as Independent Units with Different Binding Preferences for PPxY Motif-Containing Ligands

YAP is a WW domain-containing effector of the Hippo tumor suppressor pathway, and the object of heightened interest as a potent oncogene and stemness factor. YAP has two major isoforms that differ in the number of WW domains they harbor. Elucidating the degree of co-operation between these WW domain...

Descripción completa

Detalles Bibliográficos
Autores principales:	Iglesias-Bexiga, Manuel, Castillo, Francisco, Cobos, Eva S., Oka, Tsutomu, Sudol, Marius, Luque, Irene
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301871/ https://www.ncbi.nlm.nih.gov/pubmed/25607641 http://dx.doi.org/10.1371/journal.pone.0113828

Ejemplares similares

Biophysical studies and NMR structure of YAP2 WW domain - LATS1 PPxY motif complexes reveal the basis of their interaction
por: Verma, Apoorva, et al.
Publicado: (2018)

Binding site plasticity in viral PPxY Late domain recognition by the third WW domain of human NEDD4
por: Iglesias-Bexiga, Manuel, et al.
Publicado: (2019)

Structural insights into the role of the WW2 domain on tandem WW–PPxY motif interactions of oxidoreductase WWOX
por: Rotem-Bamberger, Shahar, et al.
Publicado: (2022)

A Capsid-Encoded PPxY-Motif Facilitates Adenovirus Entry
por: Wodrich, Harald, et al.
Publicado: (2010)

Interactions between AMOT PPxY motifs and NEDD4L WW domains function in HIV-1 release
por: Rheinemann, Lara, et al.
Publicado: (2021)

Production in Pichia pastoris of complementary protein-based polymers with heterodimer-forming WW and PPxY domains
por: Domeradzka, Natalia E., et al.
Publicado: (2016)

Multi-layered control of Galectin-8 mediated autophagy during adenovirus cell entry through a conserved PPxY motif in the viral capsid
por: Montespan, Charlotte, et al.
Publicado: (2017)

Yes-Associated Protein (YAP) Modulates Oncogenic Features and Radiation Sensitivity in Endometrial Cancer
por: Tsujiura, Masahiro, et al.
Publicado: (2014)

HECT ubiquitin ligases link viral and cellular PPXY motifs to the vacuolar protein-sorting pathway
por: Martin-Serrano, Juan, et al.
Publicado: (2005)

The exopolyphosphatase TbrPPX1 of Trypanosoma brucei
por: Luginbuehl, Edith, et al.
Publicado: (2011)

Fermi-Dirac correlations in $Zo \to ppX$
por: Kucharczyk, M, et al.
Publicado: (2004)

ppx: Programmatic access to proteomics data repositories
por: Fondrie, William E, et al.
Publicado: (2021)

Docking analysis of verteporfin with YAP WW domain
por: Kandoussi, Ilham, et al.
Publicado: (2017)

Central role of Yes-associated protein and WW-domain-containing transcriptional co-activator with PDZ-binding motif in pancreatic cancer development
por: Rozengurt, Enrique, et al.
Publicado: (2019)

Fermi-Dirac correlations in $Z^{o} ->ppX$
por: Kucharczyk, M, et al.
Publicado: (2004)

Fermi-Dirac correlations in $Z \to ppX$ events
por: Kucharczyk, M, et al.
Publicado: (2005)

Yes-Associated Protein (YAP) Facilitates Pressure Overload–Induced Dysfunction in the Diabetic Heart
por: Ikeda, Shohei, et al.
Publicado: (2019)

Yes-associated protein (YAP) and transcriptional coactivator with a PDZ-binding motif (TAZ): a nexus between hypoxia and cancer
por: Zhao, Chenxi, et al.
Publicado: (2020)

Yes-Associated Protein 65 Localizes P62(c-Yes) to the Apical Compartment of Airway Epithelia by Association with Ebp50
por: Mohler, Peter J., et al.
Publicado: (1999)

Fermi-Dirac Correlations in $Z^{0} \to ppX$ at LEP
por: Kucharczyk, M.
Publicado: (2004)

JNK phosphorylates Yes-associated protein (YAP) to regulate apoptosis
por: Tomlinson, V, et al.
Publicado: (2010)

Dual roles of yes-associated protein (YAP) in colorectal cancer
por: Ou, Chunlin, et al.
Publicado: (2017)

A New Player in the Mechanobiology of Deep Fascia: Yes-Associated Protein (YAP)
por: Pirri, Carmelo, et al.
Publicado: (2023)

Optogenetic control of YAP can enhance the rate of wound healing
por: Toh, Pearlyn Jia Ying, et al.
Publicado: (2023)

The Lymphocytic Choriomeningitis Virus Matrix Protein PPXY Late Domain Drives the Production of Defective Interfering Particles
por: Ziegler, Christopher M., et al.
Publicado: (2016)

Increased expression of yes-associated protein/YAP and transcriptional coactivator with PDZ-binding motif/TAZ activates intestinal fibroblasts to promote intestinal obstruction in Crohn's disease
por: Ou, Weijun, et al.
Publicado: (2021)

Yes-Associated Protein (Yap) Is Required for Early Embryonic Development in Zebrafish (Danio Rerio)
por: Hu, Jingying, et al.
Publicado: (2013)

Yes-associated protein (YAP) is a negative regulator of chondrogenesis in mesenchymal stem cells
por: Karystinou, Alexandra, et al.
Publicado: (2015)

Promoter methylation of yes-associated protein (YAP1) gene in polycystic ovary syndrome
por: Jiang, Li-Le, et al.
Publicado: (2017)

The Two PPX-GppA Homologues from Mycobacterium tuberculosis Have Distinct Biochemical Activities
por: Choi, Mei Y., et al.
Publicado: (2012)

Usefulness of 5-ALA (Gliolan®)-derived PPX fluorescence for demonstrating the extent of infiltration in atypical meningiomas
por: Wilbers, Eike, et al.
Publicado: (2014)

Ddp1 Cooperates with Ppx1 to Counter a Stress Response Initiated by Nonvacuolar Polyphosphate
por: McCarthy, Liam, et al.
Publicado: (2022)

What reward does a child prefer for behaving well at the dentist?
por: Coxon, James, et al.
Publicado: (2017)

Yes-Associated Protein (Yap) Is Up-Regulated in Heart Failure and Promotes Cardiac Fibroblast Proliferation
por: Sharifi-Sanjani, Maryam, et al.
Publicado: (2021)

Changes in the folding landscape of the WW domain provide a molecular mechanism for an inherited genetic syndrome
por: Pucheta-Martinez, Encarna, et al.
Publicado: (2016)

Optogenetic control of YAP cellular localisation and function
por: Toh, Pearlyn J Y, et al.
Publicado: (2022)

Yes-Associated Protein and Transcriptional Coactivator with PDZ-Binding Motif in Cardiovascular Diseases
por: Li, Ruojun, et al.
Publicado: (2023)

Biological and clinical characterization of paclitaxel poliglumex (PPX, CT-2103), a macromolecular polymer–drug conjugate
por: Chipman, Stewart D, et al.
Publicado: (2006)

Yes-Associated Protein (Yap) Is Necessary for Ciliogenesis and Morphogenesis during Pronephros Development in Zebrafish (Danio Rerio)
por: He, Liangliang, et al.
Publicado: (2015)

Prognostic Value of Yes-Associated Protein 1 (YAP1) in Various Cancers: A Meta-Analysis
por: Sun, Zhenqiang, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_imdte5n3butg8v5hf7j19pg0h9