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Lavender oil suppresses indoleamine 2,3-dioxygenase activity in human PBMC
BACKGROUND: Lavender remedies have been used in traditional medicine because of antimicrobial, anti-inflammatory and mood alleviating effects, but underlying molecular mechanisms are not yet fully elucidated. Recently, studies investigating the effects of lavender oil in the context of psychiatric d...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301885/ https://www.ncbi.nlm.nih.gov/pubmed/25515049 http://dx.doi.org/10.1186/1472-6882-14-503 |
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author | Gostner, Johanna M Ganzera, Markus Becker, Kathrin Geisler, Simon Schroecksnadel, Sebastian Überall, Florian Schennach, Harald Fuchs, Dietmar |
author_facet | Gostner, Johanna M Ganzera, Markus Becker, Kathrin Geisler, Simon Schroecksnadel, Sebastian Überall, Florian Schennach, Harald Fuchs, Dietmar |
author_sort | Gostner, Johanna M |
collection | PubMed |
description | BACKGROUND: Lavender remedies have been used in traditional medicine because of antimicrobial, anti-inflammatory and mood alleviating effects, but underlying molecular mechanisms are not yet fully elucidated. Recently, studies investigating the effects of lavender oil in the context of psychiatric disorders have indicated potent pharmacological properties. Metabolism of tryptophan by indoleamine 2,3-dioxygenase (IDO) was found to provide a biochemical link between immunology and neuroendocrinology and to be a frequent target of natural products. METHODS: In this in vitro study, interferences of lavender oil and constituents (-)-linalool, (+)-α-pinene and (+)-limonene with tryptophan catabolism by IDO and formation of neopterin via guanosine triphosphate (GTP)-cyclohydrolase-I and of interferon-γ have been investigated using unstimulated and phytohemagglutinin (PHA)-stimulated human peripheral blood mononuclear cells (PBMC). RESULTS: Treatment with lavender oil dose-dependently suppressed PHA-induced tryptophan breakdown and kynurenine formation. Similar effects were observed for the three constituents. In parallel, formation of neopterin and interferon-γ was diminished upon lavender oil treatment. In unstimulated PBMC, effect of lavender oil treatment was similar, but less pronounced. CONCLUSION: Data from this in vitro study suggest that lavender oil treatment might contribute to the modulation of the immune and neuroendocrine system by interfering with activation-induced tryptophan breakdown and IDO activity. |
format | Online Article Text |
id | pubmed-4301885 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-43018852015-01-22 Lavender oil suppresses indoleamine 2,3-dioxygenase activity in human PBMC Gostner, Johanna M Ganzera, Markus Becker, Kathrin Geisler, Simon Schroecksnadel, Sebastian Überall, Florian Schennach, Harald Fuchs, Dietmar BMC Complement Altern Med Research Article BACKGROUND: Lavender remedies have been used in traditional medicine because of antimicrobial, anti-inflammatory and mood alleviating effects, but underlying molecular mechanisms are not yet fully elucidated. Recently, studies investigating the effects of lavender oil in the context of psychiatric disorders have indicated potent pharmacological properties. Metabolism of tryptophan by indoleamine 2,3-dioxygenase (IDO) was found to provide a biochemical link between immunology and neuroendocrinology and to be a frequent target of natural products. METHODS: In this in vitro study, interferences of lavender oil and constituents (-)-linalool, (+)-α-pinene and (+)-limonene with tryptophan catabolism by IDO and formation of neopterin via guanosine triphosphate (GTP)-cyclohydrolase-I and of interferon-γ have been investigated using unstimulated and phytohemagglutinin (PHA)-stimulated human peripheral blood mononuclear cells (PBMC). RESULTS: Treatment with lavender oil dose-dependently suppressed PHA-induced tryptophan breakdown and kynurenine formation. Similar effects were observed for the three constituents. In parallel, formation of neopterin and interferon-γ was diminished upon lavender oil treatment. In unstimulated PBMC, effect of lavender oil treatment was similar, but less pronounced. CONCLUSION: Data from this in vitro study suggest that lavender oil treatment might contribute to the modulation of the immune and neuroendocrine system by interfering with activation-induced tryptophan breakdown and IDO activity. BioMed Central 2014-12-16 /pmc/articles/PMC4301885/ /pubmed/25515049 http://dx.doi.org/10.1186/1472-6882-14-503 Text en © Gostner et al.; licensee BioMed Central. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Gostner, Johanna M Ganzera, Markus Becker, Kathrin Geisler, Simon Schroecksnadel, Sebastian Überall, Florian Schennach, Harald Fuchs, Dietmar Lavender oil suppresses indoleamine 2,3-dioxygenase activity in human PBMC |
title | Lavender oil suppresses indoleamine 2,3-dioxygenase activity in human PBMC |
title_full | Lavender oil suppresses indoleamine 2,3-dioxygenase activity in human PBMC |
title_fullStr | Lavender oil suppresses indoleamine 2,3-dioxygenase activity in human PBMC |
title_full_unstemmed | Lavender oil suppresses indoleamine 2,3-dioxygenase activity in human PBMC |
title_short | Lavender oil suppresses indoleamine 2,3-dioxygenase activity in human PBMC |
title_sort | lavender oil suppresses indoleamine 2,3-dioxygenase activity in human pbmc |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301885/ https://www.ncbi.nlm.nih.gov/pubmed/25515049 http://dx.doi.org/10.1186/1472-6882-14-503 |
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