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Potential protective effect of Tualang honey on BPA-induced ovarian toxicity in prepubertal rat

BACKGROUND: To investigate the potential protective effects of Tualang honey against the toxicity effects induced by Bisphenol A (BPA) on pubertal development of ovaries. METHODS: This study was conducted on pre-pubertal female Sprague Dawley rats. Animals were divided into four groups (n = 8 in eac...

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Autores principales: Zaid, Siti Sarah Mohamad, Othman, Shatrah, Kassim, Normadiah M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301897/
https://www.ncbi.nlm.nih.gov/pubmed/25519484
http://dx.doi.org/10.1186/1472-6882-14-509
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author Zaid, Siti Sarah Mohamad
Othman, Shatrah
Kassim, Normadiah M
author_facet Zaid, Siti Sarah Mohamad
Othman, Shatrah
Kassim, Normadiah M
author_sort Zaid, Siti Sarah Mohamad
collection PubMed
description BACKGROUND: To investigate the potential protective effects of Tualang honey against the toxicity effects induced by Bisphenol A (BPA) on pubertal development of ovaries. METHODS: This study was conducted on pre-pubertal female Sprague Dawley rats. Animals were divided into four groups (n = 8 in each group). Group I was administered with vehicle 0.2 ml of corn oil (Sigma-Aldrich, USA) using oral gavage daily for six weeks; these animals served as negative control (CO group), Group II was administered with BPA suspended in corn oil at 10 mg/kg body weight and served as positive control (PC group), Group III was administered with 200 mg/kg body weight of Tualang honey 30 min before the administration of BPA at 10 mg/kg (TH group) while Group IV was administered with 200 mg/kg body weight of Tualang honey 30 min before the administration of corn oil (THC group). Body weight of all animals were monitored weekly. RESULTS: The BPA-exposed animals exhibited disruption of their estrus cycle, while those animals treated with BPA together with Tualang honey, exhibited an improvement in percentage of normal estrous cycle. Their ovaries had lower numbers of atretic follicles compared to the PC group but higher than the CO group. CONCLUSIONS: Tualang honey has a potential role in reducing BPA-induced ovarian toxicity by reducing the morphological abnormalities of the ovarian follicles and improving the normal estrous cycle.
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spelling pubmed-43018972015-01-22 Potential protective effect of Tualang honey on BPA-induced ovarian toxicity in prepubertal rat Zaid, Siti Sarah Mohamad Othman, Shatrah Kassim, Normadiah M BMC Complement Altern Med Research Article BACKGROUND: To investigate the potential protective effects of Tualang honey against the toxicity effects induced by Bisphenol A (BPA) on pubertal development of ovaries. METHODS: This study was conducted on pre-pubertal female Sprague Dawley rats. Animals were divided into four groups (n = 8 in each group). Group I was administered with vehicle 0.2 ml of corn oil (Sigma-Aldrich, USA) using oral gavage daily for six weeks; these animals served as negative control (CO group), Group II was administered with BPA suspended in corn oil at 10 mg/kg body weight and served as positive control (PC group), Group III was administered with 200 mg/kg body weight of Tualang honey 30 min before the administration of BPA at 10 mg/kg (TH group) while Group IV was administered with 200 mg/kg body weight of Tualang honey 30 min before the administration of corn oil (THC group). Body weight of all animals were monitored weekly. RESULTS: The BPA-exposed animals exhibited disruption of their estrus cycle, while those animals treated with BPA together with Tualang honey, exhibited an improvement in percentage of normal estrous cycle. Their ovaries had lower numbers of atretic follicles compared to the PC group but higher than the CO group. CONCLUSIONS: Tualang honey has a potential role in reducing BPA-induced ovarian toxicity by reducing the morphological abnormalities of the ovarian follicles and improving the normal estrous cycle. BioMed Central 2014-12-17 /pmc/articles/PMC4301897/ /pubmed/25519484 http://dx.doi.org/10.1186/1472-6882-14-509 Text en © Zaid et al.; licensee BioMed Central. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Zaid, Siti Sarah Mohamad
Othman, Shatrah
Kassim, Normadiah M
Potential protective effect of Tualang honey on BPA-induced ovarian toxicity in prepubertal rat
title Potential protective effect of Tualang honey on BPA-induced ovarian toxicity in prepubertal rat
title_full Potential protective effect of Tualang honey on BPA-induced ovarian toxicity in prepubertal rat
title_fullStr Potential protective effect of Tualang honey on BPA-induced ovarian toxicity in prepubertal rat
title_full_unstemmed Potential protective effect of Tualang honey on BPA-induced ovarian toxicity in prepubertal rat
title_short Potential protective effect of Tualang honey on BPA-induced ovarian toxicity in prepubertal rat
title_sort potential protective effect of tualang honey on bpa-induced ovarian toxicity in prepubertal rat
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301897/
https://www.ncbi.nlm.nih.gov/pubmed/25519484
http://dx.doi.org/10.1186/1472-6882-14-509
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