Adhesion Molecule Increases in Sleep Apnea: Beneficial Effect of Positive Airway Pressure and Moderation by Obesity

BACKGROUND: Elevated levels of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) may contribute to cardiovascular disease and are associated with obstructive sleep apnea (OSA) and obesity. The relationship between OSA and obesity in determining ICAM-1 and VCAM-1 levels, and the effect of treatment, is unclear. OBJECTIVE: Our aim was to study whether positive airway pressure (PAP) usage resulted in changes in ICAM-1 and VCAM-1 after 2 years within 309 OSA patients from the Icelandic Sleep Apnea Cohort, and determine how obesity affected such changes. SUBJECTS/METHODS: The mean body mass index (BMI) was 32.4±5.1 kg/m(2); subjects had moderate-to-severe OSA (apnea-hypopnea index = 45.0±20.2) and 79% were male. There were 177 full PAP users (≥4 hours/night and ≥20 of last 28 nights), 44 partial (<4 hours/night or <20 nights), and 88 non-users. RESULTS: ICAM-1 (p<0.001) and VCAM-1 (p=0.012) change was significantly different among the PAP groups. The largest ICAM-1 differences were among the most obese subjects (p<0.001). At follow-up, non-users had increased ICAM-1 compared to decreased levels in full users. All groups had increased VCAM-1, but non-users had a significantly larger increase than full users. CONCLUSION: Within moderate-to-severe OSA patients, PAP usage prevents increases in adhesion molecules observed in non-users after two years. For ICAM-1, the largest effect is in the most obese subjects. As OSA and obesity commonly coexist, the usage of PAP to limit increases in adhesion molecules may decrease the rate of progression of OSA-related cardiovascular disease.