The number of intestinal bacteria is not critical for the enhancement of antitumor activity and reduction of intestinal toxicity of irinotecan by the Chinese herbal medicine PHY906 (KD018)

BACKGROUND: The four-herb Chinese medicine PHY906(KD018) has been shown to both enhance the in vivo antitumor activity of irinotecan (CPT-11) against colon cancer tumor allografts and alleviate intestinal toxicity caused by CPT-11. METHODS: Since intestinal bacteria can metabolize CPT-11 and PHY906,...

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Detalles Bibliográficos
Autores principales: Lam, Wing, Jiang, Zaoli, Guan, Fulan, Hu, Rong, Liu, Shwu-Huey, Chu, Edward, Cheng, Yung-Chi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302098/
https://www.ncbi.nlm.nih.gov/pubmed/25510341
http://dx.doi.org/10.1186/1472-6882-14-490

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