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Endovascular Therapy for Ischemic Stroke

The utility of intravenous tissue plasminogen activator (IV t-PA) in improving the clinical outcomes after acute ischemic stroke has been well demonstrated in past clinical trials. Though multiple initial small series of endovascular stroke therapy had shown good outcomes as compared to IV t-PA, a s...

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Detalles Bibliográficos
Autores principales: Appireddy, Ramana M R, Demchuk, Andrew M, Goyal, Mayank, Menon, Bijoy K, Eesa, Muneer, Choi, Philip, Hill, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Neurological Association 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302170/
https://www.ncbi.nlm.nih.gov/pubmed/25628731
http://dx.doi.org/10.3988/jcn.2015.11.1.1
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author Appireddy, Ramana M R
Demchuk, Andrew M
Goyal, Mayank
Menon, Bijoy K
Eesa, Muneer
Choi, Philip
Hill, Michael D.
author_facet Appireddy, Ramana M R
Demchuk, Andrew M
Goyal, Mayank
Menon, Bijoy K
Eesa, Muneer
Choi, Philip
Hill, Michael D.
author_sort Appireddy, Ramana M R
collection PubMed
description The utility of intravenous tissue plasminogen activator (IV t-PA) in improving the clinical outcomes after acute ischemic stroke has been well demonstrated in past clinical trials. Though multiple initial small series of endovascular stroke therapy had shown good outcomes as compared to IV t-PA, a similar beneficial effect had not been translated in multiple randomized clinical trials of endovascular stroke therapy. Over the same time, there have been parallel advances in imaging technology and better understanding and utility of the imaging in therapy of acute stroke. In this review, we will discuss the evolution of endovascular stroke therapy followed by a discussion of the key factors that have to be considered during endovascular stroke therapy and directions for future endovascular stroke trials.
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spelling pubmed-43021702015-01-27 Endovascular Therapy for Ischemic Stroke Appireddy, Ramana M R Demchuk, Andrew M Goyal, Mayank Menon, Bijoy K Eesa, Muneer Choi, Philip Hill, Michael D. J Clin Neurol Review The utility of intravenous tissue plasminogen activator (IV t-PA) in improving the clinical outcomes after acute ischemic stroke has been well demonstrated in past clinical trials. Though multiple initial small series of endovascular stroke therapy had shown good outcomes as compared to IV t-PA, a similar beneficial effect had not been translated in multiple randomized clinical trials of endovascular stroke therapy. Over the same time, there have been parallel advances in imaging technology and better understanding and utility of the imaging in therapy of acute stroke. In this review, we will discuss the evolution of endovascular stroke therapy followed by a discussion of the key factors that have to be considered during endovascular stroke therapy and directions for future endovascular stroke trials. Korean Neurological Association 2015-01 2015-01-02 /pmc/articles/PMC4302170/ /pubmed/25628731 http://dx.doi.org/10.3988/jcn.2015.11.1.1 Text en Copyright © 2015 Korean Neurological Association http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Appireddy, Ramana M R
Demchuk, Andrew M
Goyal, Mayank
Menon, Bijoy K
Eesa, Muneer
Choi, Philip
Hill, Michael D.
Endovascular Therapy for Ischemic Stroke
title Endovascular Therapy for Ischemic Stroke
title_full Endovascular Therapy for Ischemic Stroke
title_fullStr Endovascular Therapy for Ischemic Stroke
title_full_unstemmed Endovascular Therapy for Ischemic Stroke
title_short Endovascular Therapy for Ischemic Stroke
title_sort endovascular therapy for ischemic stroke
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302170/
https://www.ncbi.nlm.nih.gov/pubmed/25628731
http://dx.doi.org/10.3988/jcn.2015.11.1.1
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