The translational significance of epithelial-mesenchymal transition in head and neck cancer

Positive markers of epithelial-mesenchymal transition (EMT) in head and neck cancers complicate clinical management and are associated with reduced survival. We discuss recent translational discoveries in EMT and suggest additional actionable molecular pathways, biomarkers, and clinical agents. ELEC...

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Detalles Bibliográficos
Autores principales: Graves, Christian A, Abboodi, Fadi F, Tomar, Swati, Wells, James, Pirisi, Lucia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302251/
https://www.ncbi.nlm.nih.gov/pubmed/25632320
http://dx.doi.org/10.1186/s40169-014-0039-9
Descripción
Sumario:Positive markers of epithelial-mesenchymal transition (EMT) in head and neck cancers complicate clinical management and are associated with reduced survival. We discuss recent translational discoveries in EMT and suggest additional actionable molecular pathways, biomarkers, and clinical agents. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s40169-014-0039-9) contains supplementary material, which is available to authorized users.

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