The translational significance of epithelial-mesenchymal transition in head and neck cancer

Positive markers of epithelial-mesenchymal transition (EMT) in head and neck cancers complicate clinical management and are associated with reduced survival. We discuss recent translational discoveries in EMT and suggest additional actionable molecular pathways, biomarkers, and clinical agents. ELEC...

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Detalles Bibliográficos
Autores principales: Graves, Christian A, Abboodi, Fadi F, Tomar, Swati, Wells, James, Pirisi, Lucia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302251/
https://www.ncbi.nlm.nih.gov/pubmed/25632320
http://dx.doi.org/10.1186/s40169-014-0039-9
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author Graves, Christian A
Abboodi, Fadi F
Tomar, Swati
Wells, James
Pirisi, Lucia
author_facet Graves, Christian A
Abboodi, Fadi F
Tomar, Swati
Wells, James
Pirisi, Lucia
author_sort Graves, Christian A
collection PubMed
description Positive markers of epithelial-mesenchymal transition (EMT) in head and neck cancers complicate clinical management and are associated with reduced survival. We discuss recent translational discoveries in EMT and suggest additional actionable molecular pathways, biomarkers, and clinical agents. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s40169-014-0039-9) contains supplementary material, which is available to authorized users.
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spelling pubmed-43022512015-01-26 The translational significance of epithelial-mesenchymal transition in head and neck cancer Graves, Christian A Abboodi, Fadi F Tomar, Swati Wells, James Pirisi, Lucia Clin Transl Med Review Positive markers of epithelial-mesenchymal transition (EMT) in head and neck cancers complicate clinical management and are associated with reduced survival. We discuss recent translational discoveries in EMT and suggest additional actionable molecular pathways, biomarkers, and clinical agents. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s40169-014-0039-9) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2014-11-30 /pmc/articles/PMC4302251/ /pubmed/25632320 http://dx.doi.org/10.1186/s40169-014-0039-9 Text en © Graves et al.; licensee Springer. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
spellingShingle Review
Graves, Christian A
Abboodi, Fadi F
Tomar, Swati
Wells, James
Pirisi, Lucia
The translational significance of epithelial-mesenchymal transition in head and neck cancer
title The translational significance of epithelial-mesenchymal transition in head and neck cancer
title_full The translational significance of epithelial-mesenchymal transition in head and neck cancer
title_fullStr The translational significance of epithelial-mesenchymal transition in head and neck cancer
title_full_unstemmed The translational significance of epithelial-mesenchymal transition in head and neck cancer
title_short The translational significance of epithelial-mesenchymal transition in head and neck cancer
title_sort translational significance of epithelial-mesenchymal transition in head and neck cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302251/
https://www.ncbi.nlm.nih.gov/pubmed/25632320
http://dx.doi.org/10.1186/s40169-014-0039-9
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