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Potent effects of dioscin against obesity in mice
The mechanisms of the natural product dioscin against non-alcoholic fatty liver disease (NAFLD) are unclear. Thus, the purpose of the present study was to further confirm its effects of prevention and then to elucidate the potential mechanisms underlying its activity in mice. High-fat diet (HFD)-ind...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302319/ https://www.ncbi.nlm.nih.gov/pubmed/25609476 http://dx.doi.org/10.1038/srep07973 |
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author | Liu, Min Xu, Lina Yin, Lianhong Qi, Yan Xu, Youwei Han, Xu Zhao, Yanyan Sun, Huijun Yao, Jihong Lin, Yuan Liu, Kexin Peng, Jinyong |
author_facet | Liu, Min Xu, Lina Yin, Lianhong Qi, Yan Xu, Youwei Han, Xu Zhao, Yanyan Sun, Huijun Yao, Jihong Lin, Yuan Liu, Kexin Peng, Jinyong |
author_sort | Liu, Min |
collection | PubMed |
description | The mechanisms of the natural product dioscin against non-alcoholic fatty liver disease (NAFLD) are unclear. Thus, the purpose of the present study was to further confirm its effects of prevention and then to elucidate the potential mechanisms underlying its activity in mice. High-fat diet (HFD)-induced C57BL/6J mice and ob/ob mice were used as the experimental models. Serum and hepatic biochemical parameters were determined, and the mRNA and protein expression levels were detected. The results indicated that dioscin alleviated body weight and liver lipid accumulation symptoms, increased oxygen consumption and energy expenditure, and improved the levels of serum and hepatic biochemical parameters. Further investigations revealed that dioscin significantly attenuated oxidative damage, suppressed inflammation, inhibited triglyceride and cholesterol synthesis, promoted fatty acid β-oxidation, down-regulated MAPK phosphorylation levels, and induced autophagy to alleviate fatty liver conditions. Dioscin prevents diet induced obesity and NAFLD by increasing energy expenditure. This agent should be developed as a new candidate for obesity and NAFLD prevention. |
format | Online Article Text |
id | pubmed-4302319 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-43023192015-01-27 Potent effects of dioscin against obesity in mice Liu, Min Xu, Lina Yin, Lianhong Qi, Yan Xu, Youwei Han, Xu Zhao, Yanyan Sun, Huijun Yao, Jihong Lin, Yuan Liu, Kexin Peng, Jinyong Sci Rep Article The mechanisms of the natural product dioscin against non-alcoholic fatty liver disease (NAFLD) are unclear. Thus, the purpose of the present study was to further confirm its effects of prevention and then to elucidate the potential mechanisms underlying its activity in mice. High-fat diet (HFD)-induced C57BL/6J mice and ob/ob mice were used as the experimental models. Serum and hepatic biochemical parameters were determined, and the mRNA and protein expression levels were detected. The results indicated that dioscin alleviated body weight and liver lipid accumulation symptoms, increased oxygen consumption and energy expenditure, and improved the levels of serum and hepatic biochemical parameters. Further investigations revealed that dioscin significantly attenuated oxidative damage, suppressed inflammation, inhibited triglyceride and cholesterol synthesis, promoted fatty acid β-oxidation, down-regulated MAPK phosphorylation levels, and induced autophagy to alleviate fatty liver conditions. Dioscin prevents diet induced obesity and NAFLD by increasing energy expenditure. This agent should be developed as a new candidate for obesity and NAFLD prevention. Nature Publishing Group 2015-01-22 /pmc/articles/PMC4302319/ /pubmed/25609476 http://dx.doi.org/10.1038/srep07973 Text en Copyright © 2015, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-sa/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/ |
spellingShingle | Article Liu, Min Xu, Lina Yin, Lianhong Qi, Yan Xu, Youwei Han, Xu Zhao, Yanyan Sun, Huijun Yao, Jihong Lin, Yuan Liu, Kexin Peng, Jinyong Potent effects of dioscin against obesity in mice |
title | Potent effects of dioscin against obesity in mice |
title_full | Potent effects of dioscin against obesity in mice |
title_fullStr | Potent effects of dioscin against obesity in mice |
title_full_unstemmed | Potent effects of dioscin against obesity in mice |
title_short | Potent effects of dioscin against obesity in mice |
title_sort | potent effects of dioscin against obesity in mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302319/ https://www.ncbi.nlm.nih.gov/pubmed/25609476 http://dx.doi.org/10.1038/srep07973 |
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