Transmission of tularemia from a water source by transstadial maintenance in a mosquito vector

Mosquitoes are thought to function as mechanical vectors of Francisella tularensis subspecies holarctica (F. t. holarctica) causing tularemia in humans. We investigated the clinical relevance of transstadially maintained F. t. holarctica in mosquitoes. Aedes egypti larvae exposed to a fully virulent...

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Autores principales: Bäckman, Stina, Näslund, Jonas, Forsman, Mats, Thelaus, Johanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302321/
https://www.ncbi.nlm.nih.gov/pubmed/25609657
http://dx.doi.org/10.1038/srep07793
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author Bäckman, Stina
Näslund, Jonas
Forsman, Mats
Thelaus, Johanna
author_facet Bäckman, Stina
Näslund, Jonas
Forsman, Mats
Thelaus, Johanna
author_sort Bäckman, Stina
collection PubMed
description Mosquitoes are thought to function as mechanical vectors of Francisella tularensis subspecies holarctica (F. t. holarctica) causing tularemia in humans. We investigated the clinical relevance of transstadially maintained F. t. holarctica in mosquitoes. Aedes egypti larvae exposed to a fully virulent F. t. holarctica strain for 24 hours, were allowed to develop into adults when they were individually homogenized. Approximately 24% of the homogenates tested positive for F. t. DNA in PCR. Mice injected with the mosquito homogenates acquired tularemia within 5 days. This novel finding demonstrates the possibility of transmission of bacteria by adult mosquitoes having acquired the pathogen from their aquatic larval habitats.
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spelling pubmed-43023212015-01-27 Transmission of tularemia from a water source by transstadial maintenance in a mosquito vector Bäckman, Stina Näslund, Jonas Forsman, Mats Thelaus, Johanna Sci Rep Article Mosquitoes are thought to function as mechanical vectors of Francisella tularensis subspecies holarctica (F. t. holarctica) causing tularemia in humans. We investigated the clinical relevance of transstadially maintained F. t. holarctica in mosquitoes. Aedes egypti larvae exposed to a fully virulent F. t. holarctica strain for 24 hours, were allowed to develop into adults when they were individually homogenized. Approximately 24% of the homogenates tested positive for F. t. DNA in PCR. Mice injected with the mosquito homogenates acquired tularemia within 5 days. This novel finding demonstrates the possibility of transmission of bacteria by adult mosquitoes having acquired the pathogen from their aquatic larval habitats. Nature Publishing Group 2015-01-22 /pmc/articles/PMC4302321/ /pubmed/25609657 http://dx.doi.org/10.1038/srep07793 Text en Copyright © 2015, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Article
Bäckman, Stina
Näslund, Jonas
Forsman, Mats
Thelaus, Johanna
Transmission of tularemia from a water source by transstadial maintenance in a mosquito vector
title Transmission of tularemia from a water source by transstadial maintenance in a mosquito vector
title_full Transmission of tularemia from a water source by transstadial maintenance in a mosquito vector
title_fullStr Transmission of tularemia from a water source by transstadial maintenance in a mosquito vector
title_full_unstemmed Transmission of tularemia from a water source by transstadial maintenance in a mosquito vector
title_short Transmission of tularemia from a water source by transstadial maintenance in a mosquito vector
title_sort transmission of tularemia from a water source by transstadial maintenance in a mosquito vector
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302321/
https://www.ncbi.nlm.nih.gov/pubmed/25609657
http://dx.doi.org/10.1038/srep07793
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