A reduction of viral mRNA, proteins and induction of altered morphogenesis reveals the anti-HTLV-1 activity of the labdane-diterpene myriadenolide in vitro

BACKGROUND: Human T-lymphotropic virus 1 (HTLV-1) has been associated with leukemia/lymphoma (ATL) and myelopathy/tropical spastic paraparesis (HAM/TSP), in addition to other inflammatory diseases as well as infection complications. Therapeutic approaches for HTLV-1-related pathologies are limited....

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Detalles Bibliográficos
Autores principales: Martins, Camila Pacheco Silveira, Gomes, Orlando Abreu, Martins, Marina Lobato, de Carvalho, Luciana Debortoli, de Souza, Jaqueline Gontijo, Da Fonseca, Flavio Guimaraes, dos Santos, Rodrigo Gonçalves Silva, Andrade, Margareth Spangler, Zani, Carlos Leomar, de Souza-Fagundes, Elaine Maria, Barbosa-Stancioli, Edel Figueiredo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302425/
https://www.ncbi.nlm.nih.gov/pubmed/25539906
http://dx.doi.org/10.1186/s12866-014-0331-2

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