Sonic hedgehog elevates N-myc gene expression in neural stem cells★

Proliferation of neural stem cells is regulated by the secreted signaling molecule sonic hedgehog. In this study, neural stem cells were infected with recombinant adeno-associated virus expressing sonic hedgehog-N-enhanced green fluorescent protein. The results showed that overexpression of sonic he...

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Autores principales: Liu, Dongsheng, Wang, Shouyu, Cui, Yan, Shen, Lun, Du, Yanping, Li, Guilin, Zhang, Bo, Wang, Renzhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Research and Report: Stem Cells and Neural Regeneration
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302450/
https://www.ncbi.nlm.nih.gov/pubmed/25624791
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.22.004
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author Liu, Dongsheng
Wang, Shouyu
Cui, Yan
Shen, Lun
Du, Yanping
Li, Guilin
Zhang, Bo
Wang, Renzhi
author_facet Liu, Dongsheng
Wang, Shouyu
Cui, Yan
Shen, Lun
Du, Yanping
Li, Guilin
Zhang, Bo
Wang, Renzhi
author_sort Liu, Dongsheng
collection PubMed
description Proliferation of neural stem cells is regulated by the secreted signaling molecule sonic hedgehog. In this study, neural stem cells were infected with recombinant adeno-associated virus expressing sonic hedgehog-N-enhanced green fluorescent protein. The results showed that overexpression of sonic hedgehog in neural stem cells induced the increased expression of Gli1 and N-myc, a target gene of sonic hedgehog. These findings suggest that N-myc is a direct downstream target of the sonic hedgehog signal pathway in neural stem cells. Sonic hedgehog and N-myc are important mediators of sonic hedgehog-induced proliferation of neural stem cells.
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spelling pubmed-43024502015-01-26 Sonic hedgehog elevates N-myc gene expression in neural stem cells★ Liu, Dongsheng Wang, Shouyu Cui, Yan Shen, Lun Du, Yanping Li, Guilin Zhang, Bo Wang, Renzhi Neural Regen Res Research and Report: Stem Cells and Neural Regeneration Proliferation of neural stem cells is regulated by the secreted signaling molecule sonic hedgehog. In this study, neural stem cells were infected with recombinant adeno-associated virus expressing sonic hedgehog-N-enhanced green fluorescent protein. The results showed that overexpression of sonic hedgehog in neural stem cells induced the increased expression of Gli1 and N-myc, a target gene of sonic hedgehog. These findings suggest that N-myc is a direct downstream target of the sonic hedgehog signal pathway in neural stem cells. Sonic hedgehog and N-myc are important mediators of sonic hedgehog-induced proliferation of neural stem cells. Medknow Publications & Media Pvt Ltd 2012-08-05 /pmc/articles/PMC4302450/ /pubmed/25624791 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.22.004 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research and Report: Stem Cells and Neural Regeneration
Liu, Dongsheng
Wang, Shouyu
Cui, Yan
Shen, Lun
Du, Yanping
Li, Guilin
Zhang, Bo
Wang, Renzhi
Sonic hedgehog elevates N-myc gene expression in neural stem cells★
title Sonic hedgehog elevates N-myc gene expression in neural stem cells★
title_full Sonic hedgehog elevates N-myc gene expression in neural stem cells★
title_fullStr Sonic hedgehog elevates N-myc gene expression in neural stem cells★
title_full_unstemmed Sonic hedgehog elevates N-myc gene expression in neural stem cells★
title_short Sonic hedgehog elevates N-myc gene expression in neural stem cells★
title_sort sonic hedgehog elevates n-myc gene expression in neural stem cells★
topic Research and Report: Stem Cells and Neural Regeneration
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302450/
https://www.ncbi.nlm.nih.gov/pubmed/25624791
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.22.004
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