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Regression Rate of Posterior Uveal Melanomas Following Iodine-125 Plaque Radiotherapy

AIM: To characterize the regression rate of posterior uveal melanoma following radioactive iodine-125 (I-125) plaque. MATERIALS AND METHODS: We retrospectively analyzed 95 patients with posterior uveal melanoma who were treated with only radioactive I-125 plaque and had more than 3 years follow-up....

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Autores principales: Demirci, Hakan, Saponara, Fiorella, Khan, Adam, Niziol, Leslie M., Lee, Choonik, Hayman, James A., Comer, Grant, Musch, David C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302463/
https://www.ncbi.nlm.nih.gov/pubmed/25624683
http://dx.doi.org/10.4103/0974-9233.148358
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author Demirci, Hakan
Saponara, Fiorella
Khan, Adam
Niziol, Leslie M.
Lee, Choonik
Hayman, James A.
Comer, Grant
Musch, David C.
author_facet Demirci, Hakan
Saponara, Fiorella
Khan, Adam
Niziol, Leslie M.
Lee, Choonik
Hayman, James A.
Comer, Grant
Musch, David C.
author_sort Demirci, Hakan
collection PubMed
description AIM: To characterize the regression rate of posterior uveal melanoma following radioactive iodine-125 (I-125) plaque. MATERIALS AND METHODS: We retrospectively analyzed 95 patients with posterior uveal melanoma who were treated with only radioactive I-125 plaque and had more than 3 years follow-up. All patients were treated with plaque radiotherapy using tumor dose of 85 Gy at the tumor apex, following COMS protocol. Regression rate was assessed with standardized A-scan ultrasonography. Associations with tumor regression were evaluated by means of mixed linear regression modeling. RESULTS: Mean decrease in the tumor thickness (% original thickness) at 12, 24, and 36 months after radiotherapy for melanomas <3 mm in thickness was 29%, 38%, and 45%, for melanoma 3-8 mm in thickness was 32%, 44%, and 59%, and for melanoma more than 8 mm in thickness was 52%, 62%, and 68%, respectively. With a doubling of follow-up time (0.5-1 year, or 1-2 years of follow-up from treatment), tumors <3 mm in thickness at treatment showed a 0.5 mm decrease in tumor thickness, whereas melanomas 3-8 mm showed a 1 mm decrease, and melanomas >8 mm showed a 1.7 mm decrease. Uveal melanomas that developed systemic metastasis showed an additional 0.4 mm decrease with a doubling of follow-up time from treatment, compared with those that did not develop metastasis (P = 0.050). CONCLUSIONS: Posterior uveal melanomas with higher initial thickness show steeper and more reduction in tumor thickness following radioactive I-125 plaque. After the initial phases, the regression curve became similar for tumors with different thicknesses.
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spelling pubmed-43024632015-01-26 Regression Rate of Posterior Uveal Melanomas Following Iodine-125 Plaque Radiotherapy Demirci, Hakan Saponara, Fiorella Khan, Adam Niziol, Leslie M. Lee, Choonik Hayman, James A. Comer, Grant Musch, David C. Middle East Afr J Ophthalmol Original Article AIM: To characterize the regression rate of posterior uveal melanoma following radioactive iodine-125 (I-125) plaque. MATERIALS AND METHODS: We retrospectively analyzed 95 patients with posterior uveal melanoma who were treated with only radioactive I-125 plaque and had more than 3 years follow-up. All patients were treated with plaque radiotherapy using tumor dose of 85 Gy at the tumor apex, following COMS protocol. Regression rate was assessed with standardized A-scan ultrasonography. Associations with tumor regression were evaluated by means of mixed linear regression modeling. RESULTS: Mean decrease in the tumor thickness (% original thickness) at 12, 24, and 36 months after radiotherapy for melanomas <3 mm in thickness was 29%, 38%, and 45%, for melanoma 3-8 mm in thickness was 32%, 44%, and 59%, and for melanoma more than 8 mm in thickness was 52%, 62%, and 68%, respectively. With a doubling of follow-up time (0.5-1 year, or 1-2 years of follow-up from treatment), tumors <3 mm in thickness at treatment showed a 0.5 mm decrease in tumor thickness, whereas melanomas 3-8 mm showed a 1 mm decrease, and melanomas >8 mm showed a 1.7 mm decrease. Uveal melanomas that developed systemic metastasis showed an additional 0.4 mm decrease with a doubling of follow-up time from treatment, compared with those that did not develop metastasis (P = 0.050). CONCLUSIONS: Posterior uveal melanomas with higher initial thickness show steeper and more reduction in tumor thickness following radioactive I-125 plaque. After the initial phases, the regression curve became similar for tumors with different thicknesses. Medknow Publications & Media Pvt Ltd 2015 /pmc/articles/PMC4302463/ /pubmed/25624683 http://dx.doi.org/10.4103/0974-9233.148358 Text en Copyright: © Middle East African Journal of Ophthalmology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Demirci, Hakan
Saponara, Fiorella
Khan, Adam
Niziol, Leslie M.
Lee, Choonik
Hayman, James A.
Comer, Grant
Musch, David C.
Regression Rate of Posterior Uveal Melanomas Following Iodine-125 Plaque Radiotherapy
title Regression Rate of Posterior Uveal Melanomas Following Iodine-125 Plaque Radiotherapy
title_full Regression Rate of Posterior Uveal Melanomas Following Iodine-125 Plaque Radiotherapy
title_fullStr Regression Rate of Posterior Uveal Melanomas Following Iodine-125 Plaque Radiotherapy
title_full_unstemmed Regression Rate of Posterior Uveal Melanomas Following Iodine-125 Plaque Radiotherapy
title_short Regression Rate of Posterior Uveal Melanomas Following Iodine-125 Plaque Radiotherapy
title_sort regression rate of posterior uveal melanomas following iodine-125 plaque radiotherapy
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302463/
https://www.ncbi.nlm.nih.gov/pubmed/25624683
http://dx.doi.org/10.4103/0974-9233.148358
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