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Outcome of supratentorial intraaxial extra ventricular primary pediatric brain tumors: A prospective study
INTRODUCTION: Tumors of the central nervous system (CNS) are the second most frequent malignancy of childhood and the most common solid tumor in this age group. CNS tumors represent approximately 17% of all malignancies in the pediatric age range, including adolescents. Glial neoplasms in children a...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302539/ https://www.ncbi.nlm.nih.gov/pubmed/25624922 http://dx.doi.org/10.4103/1817-1745.147571 |
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author | Patibandla, Mohana Rao Bhattacharjee, Suchanda Uppin, Megha S. Purohit, Aniruddh Kumar |
author_facet | Patibandla, Mohana Rao Bhattacharjee, Suchanda Uppin, Megha S. Purohit, Aniruddh Kumar |
author_sort | Patibandla, Mohana Rao |
collection | PubMed |
description | INTRODUCTION: Tumors of the central nervous system (CNS) are the second most frequent malignancy of childhood and the most common solid tumor in this age group. CNS tumors represent approximately 17% of all malignancies in the pediatric age range, including adolescents. Glial neoplasms in children account for up to 60% of supratentorial intraaxial tumors. Their histological distribution and prognostic features differ from that of adults. AIMS AND OBJECTIVES: To study clinical and pathological characteristics, and to analyze the outcome using the Engel's classification for seizures, Karnofsky's score during the available follow-up period of minimum 1 year following the surgical and adjuvant therapy of supratentorial intraaxial extraventricular primary pediatric (SIEPP) brain tumors in children equal or less than 18 years. MATERIALS AND METHODS: The study design is a prospective study done in NIMS from October 2008 to January 2012. All the patients less than 18 years of age operated for SIEPP brain tumors proven histopathologically were included in the study. All the patients with recurrent or residual primary tumors or secondaries were excluded from the study. Post operative CT or magnetic resonance imaging (MRI) is done following surgery. RESULTS AND ANALYSIS: There were 2, 8 and 20 patients in the age range of 0-2 years, >2-10 years and 10-18 years, respectively. There were 21 male patients and 9 female patients. Out of 30 patients, 16 had lesion in the temporal lobe, 6 in frontal lobe, 4 in thalamus, 3 in parietal lobe and 1 in occipital lobe. Out of 30 patients, 11 patients had malignant lesions and nineteen patients had benign lesions. Gross total excision could be achieved in 19 patients and subtotal in 11 patients. Seven patients had mortality and four of the remaining 23 patients had increased deficits postoperatively. Remaining 19 patients either improved or remained same. CONCLUSIONS: SIEPP brain tumors have male preponderance, occur in 95% of patients in the age range of 7-18 years and have temporal lobe as the most common site of origin. The seizure presentation has good outcome compared to raised intracranial pressure features. The seizure control is quite good irrespective of subtotal or gross total excision in temporal lobe low grade tumors. All PNETs have survival of less than 1 year even with adjuvant chemo and radiotherapy. |
format | Online Article Text |
id | pubmed-4302539 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-43025392015-01-26 Outcome of supratentorial intraaxial extra ventricular primary pediatric brain tumors: A prospective study Patibandla, Mohana Rao Bhattacharjee, Suchanda Uppin, Megha S. Purohit, Aniruddh Kumar J Pediatr Neurosci Original Article INTRODUCTION: Tumors of the central nervous system (CNS) are the second most frequent malignancy of childhood and the most common solid tumor in this age group. CNS tumors represent approximately 17% of all malignancies in the pediatric age range, including adolescents. Glial neoplasms in children account for up to 60% of supratentorial intraaxial tumors. Their histological distribution and prognostic features differ from that of adults. AIMS AND OBJECTIVES: To study clinical and pathological characteristics, and to analyze the outcome using the Engel's classification for seizures, Karnofsky's score during the available follow-up period of minimum 1 year following the surgical and adjuvant therapy of supratentorial intraaxial extraventricular primary pediatric (SIEPP) brain tumors in children equal or less than 18 years. MATERIALS AND METHODS: The study design is a prospective study done in NIMS from October 2008 to January 2012. All the patients less than 18 years of age operated for SIEPP brain tumors proven histopathologically were included in the study. All the patients with recurrent or residual primary tumors or secondaries were excluded from the study. Post operative CT or magnetic resonance imaging (MRI) is done following surgery. RESULTS AND ANALYSIS: There were 2, 8 and 20 patients in the age range of 0-2 years, >2-10 years and 10-18 years, respectively. There were 21 male patients and 9 female patients. Out of 30 patients, 16 had lesion in the temporal lobe, 6 in frontal lobe, 4 in thalamus, 3 in parietal lobe and 1 in occipital lobe. Out of 30 patients, 11 patients had malignant lesions and nineteen patients had benign lesions. Gross total excision could be achieved in 19 patients and subtotal in 11 patients. Seven patients had mortality and four of the remaining 23 patients had increased deficits postoperatively. Remaining 19 patients either improved or remained same. CONCLUSIONS: SIEPP brain tumors have male preponderance, occur in 95% of patients in the age range of 7-18 years and have temporal lobe as the most common site of origin. The seizure presentation has good outcome compared to raised intracranial pressure features. The seizure control is quite good irrespective of subtotal or gross total excision in temporal lobe low grade tumors. All PNETs have survival of less than 1 year even with adjuvant chemo and radiotherapy. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4302539/ /pubmed/25624922 http://dx.doi.org/10.4103/1817-1745.147571 Text en Copyright: © Journal of Pediatric Neurosciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Patibandla, Mohana Rao Bhattacharjee, Suchanda Uppin, Megha S. Purohit, Aniruddh Kumar Outcome of supratentorial intraaxial extra ventricular primary pediatric brain tumors: A prospective study |
title | Outcome of supratentorial intraaxial extra ventricular primary pediatric brain tumors: A prospective study |
title_full | Outcome of supratentorial intraaxial extra ventricular primary pediatric brain tumors: A prospective study |
title_fullStr | Outcome of supratentorial intraaxial extra ventricular primary pediatric brain tumors: A prospective study |
title_full_unstemmed | Outcome of supratentorial intraaxial extra ventricular primary pediatric brain tumors: A prospective study |
title_short | Outcome of supratentorial intraaxial extra ventricular primary pediatric brain tumors: A prospective study |
title_sort | outcome of supratentorial intraaxial extra ventricular primary pediatric brain tumors: a prospective study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302539/ https://www.ncbi.nlm.nih.gov/pubmed/25624922 http://dx.doi.org/10.4103/1817-1745.147571 |
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