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Spontaneous dense array gamma activity in children and adolescents with volatile solvent dependence

OBJECTIVES: Children and adolescents with volatile solvent/inhalant dependence have neurocognitive deficits. The study aimed to explore resting state gamma activity, which is a marker of cognitive function, in children and adolescents with inhalant dependence. The study also investigated differences...

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Autores principales: Tikka, Sai Krishna, Parvez, Nizamuddin, Nongpiur, Arvind, Goyal, Nishant, Sinha, Vinod Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302542/
https://www.ncbi.nlm.nih.gov/pubmed/25624925
http://dx.doi.org/10.4103/1817-1745.147575
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author Tikka, Sai Krishna
Parvez, Nizamuddin
Nongpiur, Arvind
Goyal, Nishant
Sinha, Vinod Kumar
author_facet Tikka, Sai Krishna
Parvez, Nizamuddin
Nongpiur, Arvind
Goyal, Nishant
Sinha, Vinod Kumar
author_sort Tikka, Sai Krishna
collection PubMed
description OBJECTIVES: Children and adolescents with volatile solvent/inhalant dependence have neurocognitive deficits. The study aimed to explore resting state gamma activity, which is a marker of cognitive function, in children and adolescents with inhalant dependence. The study also investigated differences in gamma activity across groups differing in inhaled amounts. MATERIALS AND METHODS: Clinical and electroencephalographic (EEG) data were collected from nine patients with inhalant dependence. 30–50 Hz spectral power was calculated using Welch's averaged periodogram method. The data were analyzed using descriptive statistics, bi-variate correlation, and nonparametric Mann–Whitney U-test. RESULTS: While significant positive correlation was found between duration of dependence and gamma spectral power in left frontal region, no significant differences were found on comparison of the groups on gamma spectral power. CONCLUSION: A complex neurobiological interaction is involved in the synaptic modulation brought about by inhalant use and this could be understood by studying changes in EEG parameters especially gamma activity.
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spelling pubmed-43025422015-01-26 Spontaneous dense array gamma activity in children and adolescents with volatile solvent dependence Tikka, Sai Krishna Parvez, Nizamuddin Nongpiur, Arvind Goyal, Nishant Sinha, Vinod Kumar J Pediatr Neurosci Original Article OBJECTIVES: Children and adolescents with volatile solvent/inhalant dependence have neurocognitive deficits. The study aimed to explore resting state gamma activity, which is a marker of cognitive function, in children and adolescents with inhalant dependence. The study also investigated differences in gamma activity across groups differing in inhaled amounts. MATERIALS AND METHODS: Clinical and electroencephalographic (EEG) data were collected from nine patients with inhalant dependence. 30–50 Hz spectral power was calculated using Welch's averaged periodogram method. The data were analyzed using descriptive statistics, bi-variate correlation, and nonparametric Mann–Whitney U-test. RESULTS: While significant positive correlation was found between duration of dependence and gamma spectral power in left frontal region, no significant differences were found on comparison of the groups on gamma spectral power. CONCLUSION: A complex neurobiological interaction is involved in the synaptic modulation brought about by inhalant use and this could be understood by studying changes in EEG parameters especially gamma activity. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4302542/ /pubmed/25624925 http://dx.doi.org/10.4103/1817-1745.147575 Text en Copyright: © Journal of Pediatric Neurosciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Tikka, Sai Krishna
Parvez, Nizamuddin
Nongpiur, Arvind
Goyal, Nishant
Sinha, Vinod Kumar
Spontaneous dense array gamma activity in children and adolescents with volatile solvent dependence
title Spontaneous dense array gamma activity in children and adolescents with volatile solvent dependence
title_full Spontaneous dense array gamma activity in children and adolescents with volatile solvent dependence
title_fullStr Spontaneous dense array gamma activity in children and adolescents with volatile solvent dependence
title_full_unstemmed Spontaneous dense array gamma activity in children and adolescents with volatile solvent dependence
title_short Spontaneous dense array gamma activity in children and adolescents with volatile solvent dependence
title_sort spontaneous dense array gamma activity in children and adolescents with volatile solvent dependence
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302542/
https://www.ncbi.nlm.nih.gov/pubmed/25624925
http://dx.doi.org/10.4103/1817-1745.147575
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