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Inhibition of epidermal growth factor signaling by the cardiac glycoside ouabain in medulloblastoma

Epidermal growth factor (EGF) signaling regulates cell growth, proliferation, and differentiation. Upon receptor binding, EGF triggers cascades of downstream signaling, including the MAPK and phosphoinositide-3-kinase (PI3K)/Akt signaling pathways. Aberrant expression/activation of EGFR is found in...

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Detalles Bibliográficos
Autores principales:	Wolle, Daniel, Lee, Seung Joon, Li, Zhiqin, Litan, Alisa, Barwe, Sonali P, Langhans, Sigrid A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2014
Materias:	Cancer Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302666/ https://www.ncbi.nlm.nih.gov/pubmed/25052069 http://dx.doi.org/10.1002/cam4.314

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