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High expression of L-type amino acid transporter 1 as a prognostic marker in bile duct adenocarcinomas

Oncocytic L-type amino acid transporter (LAT) 1 may be a prognostic indicator and target of new molecular therapeutic agents against malignancies. To investigate whether LAT1 expression influence the outcomes of patients with bile duct cancer, the expression of LAT1, LAT2, CD98, and Ki-67 was invest...

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Autores principales: Yanagisawa, Nobuyuki, Hana, Kiyomi, Nakada, Norihiro, Ichinoe, Masaaki, Koizumi, Wasaburo, Endou, Hitoshi, Okayasu, Isao, Murakumo, Yoshiki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302674/
https://www.ncbi.nlm.nih.gov/pubmed/24890221
http://dx.doi.org/10.1002/cam4.272
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author Yanagisawa, Nobuyuki
Hana, Kiyomi
Nakada, Norihiro
Ichinoe, Masaaki
Koizumi, Wasaburo
Endou, Hitoshi
Okayasu, Isao
Murakumo, Yoshiki
author_facet Yanagisawa, Nobuyuki
Hana, Kiyomi
Nakada, Norihiro
Ichinoe, Masaaki
Koizumi, Wasaburo
Endou, Hitoshi
Okayasu, Isao
Murakumo, Yoshiki
author_sort Yanagisawa, Nobuyuki
collection PubMed
description Oncocytic L-type amino acid transporter (LAT) 1 may be a prognostic indicator and target of new molecular therapeutic agents against malignancies. To investigate whether LAT1 expression influence the outcomes of patients with bile duct cancer, the expression of LAT1, LAT2, CD98, and Ki-67 was investigated immunohistochemically in 134 surgically resected bile duct adenocarcinomas, including 84 distal extrahepatic bile duct adenocarcinomas, 21 hilar cholangiocarcinomas, 15 intrahepatic cholangiocarcinomas, and 14 ampullary adenocarcinomas. LAT1 expression was weakly correlated with CD98 expression and Ki-67 labeling index (LI). Kaplan–Meier analysis showed a significant difference in prognosis between patients with bile duct adenocarcinomas having LAT1-high and -low scores, whereas LAT2 and CD98 expression and Ki-67 LI were not predictive of poor prognosis. Prognosis tended to be worse in patients having tumors with LAT1-high/LAT2-low than LAT1-low/LAT2-high scores (P = 0.0686). Multivariable analyses revealed that LAT1 expression, surgical margin, pT stage were independent prognostic factors. In conclusion, aberrant overexpression of LAT1 in bile duct adenocarcinoma predicts poor prognosis, suggesting that LAT1 may be a potential target of anticancer therapy.
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spelling pubmed-43026742015-01-22 High expression of L-type amino acid transporter 1 as a prognostic marker in bile duct adenocarcinomas Yanagisawa, Nobuyuki Hana, Kiyomi Nakada, Norihiro Ichinoe, Masaaki Koizumi, Wasaburo Endou, Hitoshi Okayasu, Isao Murakumo, Yoshiki Cancer Med Clinical Cancer Research Oncocytic L-type amino acid transporter (LAT) 1 may be a prognostic indicator and target of new molecular therapeutic agents against malignancies. To investigate whether LAT1 expression influence the outcomes of patients with bile duct cancer, the expression of LAT1, LAT2, CD98, and Ki-67 was investigated immunohistochemically in 134 surgically resected bile duct adenocarcinomas, including 84 distal extrahepatic bile duct adenocarcinomas, 21 hilar cholangiocarcinomas, 15 intrahepatic cholangiocarcinomas, and 14 ampullary adenocarcinomas. LAT1 expression was weakly correlated with CD98 expression and Ki-67 labeling index (LI). Kaplan–Meier analysis showed a significant difference in prognosis between patients with bile duct adenocarcinomas having LAT1-high and -low scores, whereas LAT2 and CD98 expression and Ki-67 LI were not predictive of poor prognosis. Prognosis tended to be worse in patients having tumors with LAT1-high/LAT2-low than LAT1-low/LAT2-high scores (P = 0.0686). Multivariable analyses revealed that LAT1 expression, surgical margin, pT stage were independent prognostic factors. In conclusion, aberrant overexpression of LAT1 in bile duct adenocarcinoma predicts poor prognosis, suggesting that LAT1 may be a potential target of anticancer therapy. Blackwell Publishing Ltd 2014-10 2014-06-02 /pmc/articles/PMC4302674/ /pubmed/24890221 http://dx.doi.org/10.1002/cam4.272 Text en © 2014 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Cancer Research
Yanagisawa, Nobuyuki
Hana, Kiyomi
Nakada, Norihiro
Ichinoe, Masaaki
Koizumi, Wasaburo
Endou, Hitoshi
Okayasu, Isao
Murakumo, Yoshiki
High expression of L-type amino acid transporter 1 as a prognostic marker in bile duct adenocarcinomas
title High expression of L-type amino acid transporter 1 as a prognostic marker in bile duct adenocarcinomas
title_full High expression of L-type amino acid transporter 1 as a prognostic marker in bile duct adenocarcinomas
title_fullStr High expression of L-type amino acid transporter 1 as a prognostic marker in bile duct adenocarcinomas
title_full_unstemmed High expression of L-type amino acid transporter 1 as a prognostic marker in bile duct adenocarcinomas
title_short High expression of L-type amino acid transporter 1 as a prognostic marker in bile duct adenocarcinomas
title_sort high expression of l-type amino acid transporter 1 as a prognostic marker in bile duct adenocarcinomas
topic Clinical Cancer Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302674/
https://www.ncbi.nlm.nih.gov/pubmed/24890221
http://dx.doi.org/10.1002/cam4.272
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