Combining the pan-aurora kinase inhibitor AMG 900 with histone deacetylase inhibitors enhances antitumor activity in prostate cancer

Histone deacetylase inhibitors (HDACIs) are being tested in clinical trials for the treatment of solid tumors. While most studies have focused on the reexpression of silenced tumor suppressor genes, a number of genes/pathways are downregulated by HDACIs. This provides opportunities for combination t...

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Detalles Bibliográficos
Autores principales: Paller, Channing J, Wissing, Michel D, Mendonca, Janet, Sharma, Anup, Kim, Eugene, Kim, Hea-Soo, Kortenhorst, Madeleine S Q, Gerber, Stephanie, Rosen, Marc, Shaikh, Faraz, Zahurak, Marianna L, Rudek, Michelle A, Hammers, Hans, Rudin, Charles M, Carducci, Michael A, Kachhap, Sushant K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Clinical Cancer Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302682/
https://www.ncbi.nlm.nih.gov/pubmed/24989836
http://dx.doi.org/10.1002/cam4.289

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