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Use of percutaneous image-guided coaxial core-needle biopsy for diagnosis of intraabdominal lymphoma

Although pathological diagnosis is essential for managing malignant lymphoma, intraabdominal lesions are generally difficult to approach due to the invasiveness of abdominal surgery. Here, we report the use of percutaneous image-guided coaxial core-needle biopsy (CNB) to obtain intraabdominal specim...

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Autores principales: Shimizu, Ikuo, Okazaki, Yoichi, Takeda, Wataru, Kirihara, Takehiko, Sato, Keijiro, Fujikawa, Yuko, Ueki, Toshimitsu, Hiroshima, Yuki, Sumi, Masahiko, Ueno, Mayumi, Ichikawa, Naoaki, Kobayashi, Hikaru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302683/
https://www.ncbi.nlm.nih.gov/pubmed/25044810
http://dx.doi.org/10.1002/cam4.224
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author Shimizu, Ikuo
Okazaki, Yoichi
Takeda, Wataru
Kirihara, Takehiko
Sato, Keijiro
Fujikawa, Yuko
Ueki, Toshimitsu
Hiroshima, Yuki
Sumi, Masahiko
Ueno, Mayumi
Ichikawa, Naoaki
Kobayashi, Hikaru
author_facet Shimizu, Ikuo
Okazaki, Yoichi
Takeda, Wataru
Kirihara, Takehiko
Sato, Keijiro
Fujikawa, Yuko
Ueki, Toshimitsu
Hiroshima, Yuki
Sumi, Masahiko
Ueno, Mayumi
Ichikawa, Naoaki
Kobayashi, Hikaru
author_sort Shimizu, Ikuo
collection PubMed
description Although pathological diagnosis is essential for managing malignant lymphoma, intraabdominal lesions are generally difficult to approach due to the invasiveness of abdominal surgery. Here, we report the use of percutaneous image-guided coaxial core-needle biopsy (CNB) to obtain intraabdominal specimens for diagnosing intraabdominal lymphomas, which typically requires histopathological and immunohistochemical evaluation. We retrospectively reviewed consecutive cases involving computed tomography (CT)- or ultrasonography (US)-guided CNB to obtain pathological specimens for intraabdominal lesions from 1999 to 2011. Liver, spleen, kidney, and inguinal node biopsies were excluded. We compared CNBs with laparotomic biopsies. A total of 66 CNBs were performed for 59 patients (32 males, 27 females; median age, 63.5), including second or third repeat procedures. Overall diagnostic rate was 88.5%. None of the patients required additional surgical biopsies. Notably, the median interval between recognition of an intraabdominal mass and biopsy was only 1 day. Forty-five procedures were performed for hematological malignancies. Adequate specimens were obtained for histopathological diagnosis in 86% of cases. Flow cytometry detected lymphoma cells in 79.5% of cases. Twelve patients (nine males, three females; median age, 60) were eligible for surgical biopsy. While every postoperative course was satisfactory, median duration from lesion recognition to therapy initiation for lymphoma cases was significantly shorter for CNB than for surgical biopsy (14 vs. 35 days). While one-fourth of the patients were not eligible for the procedures, CNB is safe and highly effective for diagnosis of intraabdominal lymphomas. This method significantly improves sampling and potentially helps attain immunohistological distinction, allowing for more timely therapy initiation.
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spelling pubmed-43026832015-01-22 Use of percutaneous image-guided coaxial core-needle biopsy for diagnosis of intraabdominal lymphoma Shimizu, Ikuo Okazaki, Yoichi Takeda, Wataru Kirihara, Takehiko Sato, Keijiro Fujikawa, Yuko Ueki, Toshimitsu Hiroshima, Yuki Sumi, Masahiko Ueno, Mayumi Ichikawa, Naoaki Kobayashi, Hikaru Cancer Med Clinical Cancer Research Although pathological diagnosis is essential for managing malignant lymphoma, intraabdominal lesions are generally difficult to approach due to the invasiveness of abdominal surgery. Here, we report the use of percutaneous image-guided coaxial core-needle biopsy (CNB) to obtain intraabdominal specimens for diagnosing intraabdominal lymphomas, which typically requires histopathological and immunohistochemical evaluation. We retrospectively reviewed consecutive cases involving computed tomography (CT)- or ultrasonography (US)-guided CNB to obtain pathological specimens for intraabdominal lesions from 1999 to 2011. Liver, spleen, kidney, and inguinal node biopsies were excluded. We compared CNBs with laparotomic biopsies. A total of 66 CNBs were performed for 59 patients (32 males, 27 females; median age, 63.5), including second or third repeat procedures. Overall diagnostic rate was 88.5%. None of the patients required additional surgical biopsies. Notably, the median interval between recognition of an intraabdominal mass and biopsy was only 1 day. Forty-five procedures were performed for hematological malignancies. Adequate specimens were obtained for histopathological diagnosis in 86% of cases. Flow cytometry detected lymphoma cells in 79.5% of cases. Twelve patients (nine males, three females; median age, 60) were eligible for surgical biopsy. While every postoperative course was satisfactory, median duration from lesion recognition to therapy initiation for lymphoma cases was significantly shorter for CNB than for surgical biopsy (14 vs. 35 days). While one-fourth of the patients were not eligible for the procedures, CNB is safe and highly effective for diagnosis of intraabdominal lymphomas. This method significantly improves sampling and potentially helps attain immunohistological distinction, allowing for more timely therapy initiation. Blackwell Publishing Ltd 2014-10 2014-07-08 /pmc/articles/PMC4302683/ /pubmed/25044810 http://dx.doi.org/10.1002/cam4.224 Text en © 2014 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Cancer Research
Shimizu, Ikuo
Okazaki, Yoichi
Takeda, Wataru
Kirihara, Takehiko
Sato, Keijiro
Fujikawa, Yuko
Ueki, Toshimitsu
Hiroshima, Yuki
Sumi, Masahiko
Ueno, Mayumi
Ichikawa, Naoaki
Kobayashi, Hikaru
Use of percutaneous image-guided coaxial core-needle biopsy for diagnosis of intraabdominal lymphoma
title Use of percutaneous image-guided coaxial core-needle biopsy for diagnosis of intraabdominal lymphoma
title_full Use of percutaneous image-guided coaxial core-needle biopsy for diagnosis of intraabdominal lymphoma
title_fullStr Use of percutaneous image-guided coaxial core-needle biopsy for diagnosis of intraabdominal lymphoma
title_full_unstemmed Use of percutaneous image-guided coaxial core-needle biopsy for diagnosis of intraabdominal lymphoma
title_short Use of percutaneous image-guided coaxial core-needle biopsy for diagnosis of intraabdominal lymphoma
title_sort use of percutaneous image-guided coaxial core-needle biopsy for diagnosis of intraabdominal lymphoma
topic Clinical Cancer Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302683/
https://www.ncbi.nlm.nih.gov/pubmed/25044810
http://dx.doi.org/10.1002/cam4.224
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