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Primary squamous cell carcinomas in the thyroid gland: an individual participant data meta-analysis

Primary squamous cell carcinomas arising from the thyroid gland (SCCTh) is extremely rare diseases, which have never been fully studied. Thus, we performed a systematic review and individual participant data meta-analysis of published SCCTh cases, to understand the clinical characteristics and to id...

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Autores principales: Cho, Jae Keun, Woo, Seung-Hoon, Park, Junoh, Kim, Min-Ji, Jeong, Han-Sin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302690/
https://www.ncbi.nlm.nih.gov/pubmed/24995699
http://dx.doi.org/10.1002/cam4.287
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author Cho, Jae Keun
Woo, Seung-Hoon
Park, Junoh
Kim, Min-Ji
Jeong, Han-Sin
author_facet Cho, Jae Keun
Woo, Seung-Hoon
Park, Junoh
Kim, Min-Ji
Jeong, Han-Sin
author_sort Cho, Jae Keun
collection PubMed
description Primary squamous cell carcinomas arising from the thyroid gland (SCCTh) is extremely rare diseases, which have never been fully studied. Thus, we performed a systematic review and individual participant data meta-analysis of published SCCTh cases, to understand the clinical characteristics and to identify the prognostic factors of primary SCCTh. A literature search was conducted within Medline, EMBASE, Cochrane library databases and KoreaMed using the following Medical Subject Headings (MeSH) keywords: “primary,” “squamous,” “carcinoma,” “cancer,” and “thyroid.” Eighty-four patients' individual data from 39 articles and five patients' data in our institute were selected for analysis (N = 89). The mean age at diagnosis was 63.0 years (range, 24–90) and female preponderance (M:F = 1:2) was noted. The commonest complaint was the anterior neck mass, followed by dyspnea or dysphagia, and extension to the adjacent structure was found in 72%. The median survival was 9.0 months (95% CI, 6.0–23.0) and 3-year survival rate (3YSR) was 37.6% by Kaplan–Meier method, but only 20.1% by a shared frailty model for adjusting heterogeneity. Complete resection (R0) of tumors was the only significant prognostic factor in multivariable analysis, and the benefit of adjuvant treatment was not proved. The prognosis of patients with SCCTh is very poor (20% in 3YSR), but complete resection of disease is correlated with improved survival. To achieve complete surgical eradication of tumors, early detection and accurate diagnosis should be emphasized.
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spelling pubmed-43026902015-01-22 Primary squamous cell carcinomas in the thyroid gland: an individual participant data meta-analysis Cho, Jae Keun Woo, Seung-Hoon Park, Junoh Kim, Min-Ji Jeong, Han-Sin Cancer Med Cancer Prevention Primary squamous cell carcinomas arising from the thyroid gland (SCCTh) is extremely rare diseases, which have never been fully studied. Thus, we performed a systematic review and individual participant data meta-analysis of published SCCTh cases, to understand the clinical characteristics and to identify the prognostic factors of primary SCCTh. A literature search was conducted within Medline, EMBASE, Cochrane library databases and KoreaMed using the following Medical Subject Headings (MeSH) keywords: “primary,” “squamous,” “carcinoma,” “cancer,” and “thyroid.” Eighty-four patients' individual data from 39 articles and five patients' data in our institute were selected for analysis (N = 89). The mean age at diagnosis was 63.0 years (range, 24–90) and female preponderance (M:F = 1:2) was noted. The commonest complaint was the anterior neck mass, followed by dyspnea or dysphagia, and extension to the adjacent structure was found in 72%. The median survival was 9.0 months (95% CI, 6.0–23.0) and 3-year survival rate (3YSR) was 37.6% by Kaplan–Meier method, but only 20.1% by a shared frailty model for adjusting heterogeneity. Complete resection (R0) of tumors was the only significant prognostic factor in multivariable analysis, and the benefit of adjuvant treatment was not proved. The prognosis of patients with SCCTh is very poor (20% in 3YSR), but complete resection of disease is correlated with improved survival. To achieve complete surgical eradication of tumors, early detection and accurate diagnosis should be emphasized. Blackwell Publishing Ltd 2014-10 2014-07-04 /pmc/articles/PMC4302690/ /pubmed/24995699 http://dx.doi.org/10.1002/cam4.287 Text en © 2014 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Cancer Prevention
Cho, Jae Keun
Woo, Seung-Hoon
Park, Junoh
Kim, Min-Ji
Jeong, Han-Sin
Primary squamous cell carcinomas in the thyroid gland: an individual participant data meta-analysis
title Primary squamous cell carcinomas in the thyroid gland: an individual participant data meta-analysis
title_full Primary squamous cell carcinomas in the thyroid gland: an individual participant data meta-analysis
title_fullStr Primary squamous cell carcinomas in the thyroid gland: an individual participant data meta-analysis
title_full_unstemmed Primary squamous cell carcinomas in the thyroid gland: an individual participant data meta-analysis
title_short Primary squamous cell carcinomas in the thyroid gland: an individual participant data meta-analysis
title_sort primary squamous cell carcinomas in the thyroid gland: an individual participant data meta-analysis
topic Cancer Prevention
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302690/
https://www.ncbi.nlm.nih.gov/pubmed/24995699
http://dx.doi.org/10.1002/cam4.287
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