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The association between lifetime smoking exposure and breast cancer mortality – results from a Norwegian cohort

Several recent cohort studies have found an association between smoking and breast cancer, but the association between lifetime smoking exposure and breast cancer mortality is less well described. We examined whether smoking before breast cancer diagnosis is a predictor of breast cancer mortality in...

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Autores principales: Bjerkaas, Eivind, Parajuli, Ranjan, Engeland, Anders, Maskarinec, Gertraud, Weiderpass, Elisabete, Gram, Inger Torhild
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302695/
https://www.ncbi.nlm.nih.gov/pubmed/25073713
http://dx.doi.org/10.1002/cam4.304
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author Bjerkaas, Eivind
Parajuli, Ranjan
Engeland, Anders
Maskarinec, Gertraud
Weiderpass, Elisabete
Gram, Inger Torhild
author_facet Bjerkaas, Eivind
Parajuli, Ranjan
Engeland, Anders
Maskarinec, Gertraud
Weiderpass, Elisabete
Gram, Inger Torhild
author_sort Bjerkaas, Eivind
collection PubMed
description Several recent cohort studies have found an association between smoking and breast cancer, but the association between lifetime smoking exposure and breast cancer mortality is less well described. We examined whether smoking before breast cancer diagnosis is a predictor of breast cancer mortality in a large cohort with more than 4.1 million years of follow-up, with a special focus on women who initiated smoking before first childbirth. Information on smoking status was collected before breast cancer diagnosis and used to estimate hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) of breast cancer mortality in a cohort of 302,865 Norwegian women with 1106 breast cancer deaths. Women were enrolled between 1974 and 2003 and followed up through linkages to national registries until 31 December 2007. We found that breast cancer mortality was slightly but significantly increased for current (HR = 1.15, 95% CI 1.01–1.32) and ever (HR = 1.15, 95% CI 1.02–1.30) smokers as compared to never smokers. No statistically significantly increased mortality was found for women who initiated smoking before first childbirth, and no dose-response association was revealed for any of the different measures of smoking exposure. A large proportion of heavy smokers may have died from other causes than breast cancer during follow-up, possibly diluting our results. This study found that lifetime smoking exposure had a significantly increased risk of breast cancer mortality compared with never smokers.
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spelling pubmed-43026952015-01-22 The association between lifetime smoking exposure and breast cancer mortality – results from a Norwegian cohort Bjerkaas, Eivind Parajuli, Ranjan Engeland, Anders Maskarinec, Gertraud Weiderpass, Elisabete Gram, Inger Torhild Cancer Med Cancer Prevention Several recent cohort studies have found an association between smoking and breast cancer, but the association between lifetime smoking exposure and breast cancer mortality is less well described. We examined whether smoking before breast cancer diagnosis is a predictor of breast cancer mortality in a large cohort with more than 4.1 million years of follow-up, with a special focus on women who initiated smoking before first childbirth. Information on smoking status was collected before breast cancer diagnosis and used to estimate hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) of breast cancer mortality in a cohort of 302,865 Norwegian women with 1106 breast cancer deaths. Women were enrolled between 1974 and 2003 and followed up through linkages to national registries until 31 December 2007. We found that breast cancer mortality was slightly but significantly increased for current (HR = 1.15, 95% CI 1.01–1.32) and ever (HR = 1.15, 95% CI 1.02–1.30) smokers as compared to never smokers. No statistically significantly increased mortality was found for women who initiated smoking before first childbirth, and no dose-response association was revealed for any of the different measures of smoking exposure. A large proportion of heavy smokers may have died from other causes than breast cancer during follow-up, possibly diluting our results. This study found that lifetime smoking exposure had a significantly increased risk of breast cancer mortality compared with never smokers. Blackwell Publishing Ltd 2014-10 2014-07-30 /pmc/articles/PMC4302695/ /pubmed/25073713 http://dx.doi.org/10.1002/cam4.304 Text en © 2014 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Cancer Prevention
Bjerkaas, Eivind
Parajuli, Ranjan
Engeland, Anders
Maskarinec, Gertraud
Weiderpass, Elisabete
Gram, Inger Torhild
The association between lifetime smoking exposure and breast cancer mortality – results from a Norwegian cohort
title The association between lifetime smoking exposure and breast cancer mortality – results from a Norwegian cohort
title_full The association between lifetime smoking exposure and breast cancer mortality – results from a Norwegian cohort
title_fullStr The association between lifetime smoking exposure and breast cancer mortality – results from a Norwegian cohort
title_full_unstemmed The association between lifetime smoking exposure and breast cancer mortality – results from a Norwegian cohort
title_short The association between lifetime smoking exposure and breast cancer mortality – results from a Norwegian cohort
title_sort association between lifetime smoking exposure and breast cancer mortality – results from a norwegian cohort
topic Cancer Prevention
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302695/
https://www.ncbi.nlm.nih.gov/pubmed/25073713
http://dx.doi.org/10.1002/cam4.304
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